Matthew W Wong1, Nady Braidy, Anne Poljak, Perminder S Sachdev. 1. aCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine bBioanalytical Mass Spectrometry Facility cSchool of Medical Sciences, Faculty of Medicine, University of New South Wales dNeuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Sydney, Australia.
Abstract
PURPOSE OF REVIEW: Alzheimer's disease is the most common cause of dementia. There are still no disease modifying treatments that can cure or slow disease progression. Recently, Alzheimer's disease researchers have attempted to improve early detection and diagnostic criteria for Alzheimer's disease, with the rationale that treatment of disease, or even prevention, may be more successful during the early preclinical stages of Alzheimer's disease when neurodegenerative damage is not as widespread. As the brain has a high lipid content, lipidomics may offer novel insights into the underlying pathogenesis of Alzheimer's disease. This review reports on recent developments in the relatively unexplored field of lipidomics in Alzheimer's disease, including novel biomarkers and pathomechanisms of Alzheimer's disease. RECENT FINDINGS: Numerous biomarker panels involving phospholipids and sphingolipids have been proposed, indicating perturbed lipid metabolism in early stages of Alzheimer's disease. Future strategies targeting these metabolic changes through dietary supplementation could have therapeutic benefits in at-risk individuals. SUMMARY: Dysregulated lipid metabolism could reflect pathological changes in synaptic function and neuronal membranes, leading to cognitive decline. However, extensive validation in large independent cohorts is required before lipid biomarkers can be used clinically to assess Alzheimer's disease risk and progression.
PURPOSE OF REVIEW: Alzheimer's disease is the most common cause of dementia. There are still no disease modifying treatments that can cure or slow disease progression. Recently, Alzheimer's disease researchers have attempted to improve early detection and diagnostic criteria for Alzheimer's disease, with the rationale that treatment of disease, or even prevention, may be more successful during the early preclinical stages of Alzheimer's disease when neurodegenerative damage is not as widespread. As the brain has a high lipid content, lipidomics may offer novel insights into the underlying pathogenesis of Alzheimer's disease. This review reports on recent developments in the relatively unexplored field of lipidomics in Alzheimer's disease, including novel biomarkers and pathomechanisms of Alzheimer's disease. RECENT FINDINGS: Numerous biomarker panels involving phospholipids and sphingolipids have been proposed, indicating perturbed lipid metabolism in early stages of Alzheimer's disease. Future strategies targeting these metabolic changes through dietary supplementation could have therapeutic benefits in at-risk individuals. SUMMARY: Dysregulated lipid metabolism could reflect pathological changes in synaptic function and neuronal membranes, leading to cognitive decline. However, extensive validation in large independent cohorts is required before lipid biomarkers can be used clinically to assess Alzheimer's disease risk and progression.
Authors: Xuewei Wang; Hai Bui; Prashanthi Vemuri; Jonathan Graff-Radford; Clifford R Jack; Ronald C Petersen; Michelle M Mielke Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.160
Authors: Matthew Wai Kin Wong; Nady Braidy; Russell Pickford; Fatemeh Vafaee; John Crawford; Julia Muenchhoff; Peter Schofield; John Attia; Henry Brodaty; Perminder Sachdev; Anne Poljak Journal: PLoS One Date: 2019-03-20 Impact factor: 3.240
Authors: Mostafa J Khan; Simona G Codreanu; Sandeep Goyal; Phillip A Wages; Santosh K K Gorti; Mackenzie J Pearson; Isabel Uribe; Stacy D Sherrod; John A McLean; Ned A Porter; Renã A S Robinson Journal: Rapid Commun Mass Spectrom Date: 2020-11-30 Impact factor: 2.586