Ilaria Pezzini1, Attilio Marino2, Serena Del Turco3, Claudia Nesti4, Stefano Doccini4, Valentina Cappello5, Mauro Gemmi5, Paola Parlanti5,6, Filippo M Santorelli4, Virgilio Mattoli2, Gianni Ciofani2,7. 1. Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. 2. Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. 3. CNR, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy. 4. Molecular Medicine, IRCCS Stella Maris, Via dei Giacinti 3, 56128 Calambrone (Pisa), Italy. 5. Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Piazza San Silvestro 12, 56127 Pisa, Italy. 6. Scuola Normale Superiore, NEST, Piazza San Silvestro 12, 56127 Pisa, Italy. 7. Department of Mechanical & Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Abstract
AIM: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. MATERIALS & METHODS: In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. RESULTS & CONCLUSION: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.
AIM: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. MATERIALS & METHODS: In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. RESULTS & CONCLUSION: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.
Authors: Kenneth Reed; Nathan Bush; Zachary Burns; Gwendolyn Doherty; Thomas Foley; Matthew Milone; Kara L Maki; Michael Cromer Journal: Biomolecules Date: 2019-09-04
Authors: Roberta Dal Magro; Agostina Vitali; Stefano Fagioli; Alberto Casu; Andrea Falqui; Beatrice Formicola; Lorenzo Taiarol; Valeria Cassina; Claudia Adriana Marrano; Francesco Mantegazza; Umberto Anselmi-Tamburini; Patrizia Sommi; Francesca Re Journal: Antioxidants (Basel) Date: 2021-02-09
Authors: Elif Aplak; Claudia von Montfort; Lisa Haasler; David Stucki; Bodo Steckel; Andreas S Reichert; Wilhelm Stahl; Peter Brenneisen Journal: PLoS One Date: 2020-01-17 Impact factor: 3.240