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Literature DB >> 28000149

Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered.

Abstract

PDGFRα regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis.

Entities: Disease Gene

Keywords: Fibro/adipogenic progenitors; Fibrosis; Muscle regeneration; PDGFRα; Polyadenylation

Year: 2016 PMID： 28000149 PMCID： PMC5362578 DOI： 10.1007/s12079-016-0372-4

Source DB: PubMed Journal: J Cell Commun Signal ISSN： 1873-9601 Impact factor: 5.782

13 in total

Review 1. Roles of PDGF in animal development.

Authors: Renée V Hoch; Philippe Soriano
Journal: Development Date: 2003-10 Impact factor: 6.868

2. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.

Authors: Lorin E Olson; Philippe Soriano
Journal: Dev Cell Date: 2009-02 Impact factor: 12.270

3. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle.

Authors: Akiyoshi Uezumi; So-ichiro Fukada; Naoki Yamamoto; Shin'ichi Takeda; Kunihiro Tsuchida
Journal: Nat Cell Biol Date: 2010-01-17 Impact factor: 28.824

4. Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration.

Authors: Malea M Murphy; Jennifer A Lawson; Sam J Mathew; David A Hutcheson; Gabrielle Kardon
Journal: Development Date: 2011-09 Impact factor: 6.868

5. Connective tissue fibroblasts and Tcf4 regulate myogenesis.

Authors: Sam J Mathew; Jody M Hansen; Allyson J Merrell; Malea M Murphy; Jennifer A Lawson; David A Hutcheson; Mark S Hansen; Melinda Angus-Hill; Gabrielle Kardon
Journal: Development Date: 2011-01 Impact factor: 6.868

6. Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy.

Authors: Maria Gabriela Morales; Jaime Gutierrez; Claudio Cabello-Verrugio; Daniel Cabrera; Kenneth E Lipson; Roel Goldschmeding; Enrique Brandan
Journal: Hum Mol Genet Date: 2013-07-30 Impact factor: 6.150

7. Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis.

Authors: Osvaldo Contreras; Daniela L Rebolledo; Juan Esteban Oyarzún; Hugo C Olguín; Enrique Brandan
Journal: Cell Tissue Res Date: 2016-01-07 Impact factor: 5.249

8. Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms.

Authors: T Guy Hamilton; Richard A Klinghoffer; Philip D Corrin; Philippe Soriano
Journal: Mol Cell Biol Date: 2003-06 Impact factor: 4.272

9. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors.

Authors: Dario R Lemos; Farshad Babaeijandaghi; Marcela Low; Chih-Kai Chang; Sunny T Lee; Daniela Fiore; Regan-Heng Zhang; Anuradha Natarajan; Sergei A Nedospasov; Fabio M V Rossi
Journal: Nat Med Date: 2015-06-08 Impact factor: 53.440