Li Liu1,2, Weijing Wang1, Jianping Sun2, Zengchang Pang3,4. 1. Department of Public Health, Qingdao University Medical College, Qingdao, 266021, Shandong Province, China. 2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, 266033, Shandong Province, China. 3. Department of Public Health, Qingdao University Medical College, Qingdao, 266021, Shandong Province, China. 15726227711@163.com. 4. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, 266033, Shandong Province, China. 15726227711@163.com.
Abstract
PURPOSE: The association between famine exposure (defined as lengthy and continuous deprivation of food) during early life and type 2 diabetes (T2DM) in adulthood remains controversial. A meta-analysis was performed to better clarify the relation of famine exposure to later T2DM risk. METHODS: A systematic literature search was performed in PubMed, Web of Science, Embase and China National Knowledge Infrastructure for relevant available articles. The articles were limited to those in English or Chinese from January 1990 to June 2016. Observational studies evaluating the association between famine exposure and T2DM were included. The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of famine exposure on T2DM. The I 2 was used to assess heterogeneity, and the random effects model (REM) was adopted as the pooling method. RESULTS: We included 11 published articles with 12391 T2DM cases for this meta-analysis. A significant association of early life famine exposure with increased risk of T2DM was observed (RR = 1.38, 95% CI 1.17-1.63; I 2 = 63.4%; P heterogeneity = 0.002). Compared with the unexposed, the RRs of T2DM were 1.36 (95% CI 1.12-1.65) for fetal-infant exposed and 1.40 (95% CI 0.98-1.99) for childhood exposed. After excluding one article that had a strong effect on heterogeneity, the pooled RR was 1.46 (95% CI 1.27-1.69). CONCLUSION: The meta-analysis indicates that famine exposure during early life especially fetal-infant exposure may increase the risk of T2DM in adulthood. Measures should be taken to prevent malnutrition during important stages of growth and development to reduce the prevalence of T2DM.
PURPOSE: The association between famine exposure (defined as lengthy and continuous deprivation of food) during early life and type 2 diabetes (T2DM) in adulthood remains controversial. A meta-analysis was performed to better clarify the relation of famine exposure to later T2DM risk. METHODS: A systematic literature search was performed in PubMed, Web of Science, Embase and China National Knowledge Infrastructure for relevant available articles. The articles were limited to those in English or Chinese from January 1990 to June 2016. Observational studies evaluating the association between famine exposure and T2DM were included. The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of famine exposure on T2DM. The I 2 was used to assess heterogeneity, and the random effects model (REM) was adopted as the pooling method. RESULTS: We included 11 published articles with 12391 T2DM cases for this meta-analysis. A significant association of early life famine exposure with increased risk of T2DM was observed (RR = 1.38, 95% CI 1.17-1.63; I 2 = 63.4%; P heterogeneity = 0.002). Compared with the unexposed, the RRs of T2DM were 1.36 (95% CI 1.12-1.65) for fetal-infant exposed and 1.40 (95% CI 0.98-1.99) for childhood exposed. After excluding one article that had a strong effect on heterogeneity, the pooled RR was 1.46 (95% CI 1.27-1.69). CONCLUSION: The meta-analysis indicates that famine exposure during early life especially fetal-infant exposure may increase the risk of T2DM in adulthood. Measures should be taken to prevent malnutrition during important stages of growth and development to reduce the prevalence of T2DM.
Entities:
Keywords:
Famine exposure; Meta-analysis; Risk; Type 2 diabetes
Authors: Chao Song; Meng Wang; Zheng Chen; Yecheng Yao; Ganyu Feng; Yanning Ma; Jing Fan; Ailing Liu Journal: Int J Environ Res Public Health Date: 2020-05-22 Impact factor: 3.390
Authors: Yan Zhang; Chao Song; Meng Wang; Weiyan Gong; Yanning Ma; Zheng Chen; Ganyu Feng; Rui Wang; Hongyun Fang; Jing Fan; Ailing Liu Journal: Int J Environ Res Public Health Date: 2020-03-25 Impact factor: 3.390