Literature DB >> 27999759

Dectin-1-activated dendritic cells: A potent Th9 cell inducer for tumor immunotherapy.

Jintong Chen1, Yinghua Zhao1, Xiao Chu1, Yong Lu2, Siqing Wang1, Qing Yi3.   

Abstract

Dendritic cell (DC)-based immunotherapy has great promise for cancer treatment. We have recently demonstrated that dectin-1-activated DCs trigger potent antitumor Th9 cells in vivo. Dectin-1-activated DC-induced antitumor responses rely on the induced Th9/IL-9. These findings offer new strategies for the development of more effective DC vaccines in tumor immunotherapy.

Entities:  

Keywords:  Antitumor immunity; Dectin-1; Th9; Vaccine; dentritic cells

Year:  2016        PMID： 27999759      PMCID： PMC5139651          DOI： 10.1080/2162402X.2016.1238558

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Sipuleucel-T immunotherapy for castration-resistant prostate cancer.

Authors:  Philip W Kantoff; Celestia S Higano; Neal D Shore; E Roy Berger; Eric J Small; David F Penson; Charles H Redfern; Anna C Ferrari; Robert Dreicer; Robert B Sims; Yi Xu; Mark W Frohlich; Paul F Schellhammer
Journal:  N Engl J Med       Date:  2010-07-29       Impact factor: 91.245

Review 2.  Genomic views of STAT function in CD4+ T helper cell differentiation.

Authors:  John J O'Shea; Riitta Lahesmaa; Golnaz Vahedi; Arian Laurence; Yuka Kanno
Journal:  Nat Rev Immunol       Date:  2011-04       Impact factor: 53.106

3.  The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages.

Authors:  Philip R Taylor; Gordon D Brown; Delyth M Reid; Janet A Willment; Luisa Martinez-Pomares; Siamon Gordon; Simon Y C Wong
Journal:  J Immunol       Date:  2002-10-01       Impact factor: 5.422

4.  Th9 cells promote antitumor immune responses in vivo.

Authors:  Yong Lu; Sungyoul Hong; Haiyan Li; Jungsun Park; Bangxing Hong; Lijuan Wang; Yuhuan Zheng; Zhiqiang Liu; Jingda Xu; Jin He; Jing Yang; Jianfei Qian; Qing Yi
Journal:  J Clin Invest       Date:  2012-10-15       Impact factor: 14.808

5.  Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.

Authors:  Sonja I Gringhuis; Jeroen den Dunnen; Manja Litjens; Michiel van der Vlist; Brigitte Wevers; Sven C M Bruijns; Teunis B H Geijtenbeek
Journal:  Nat Immunol       Date:  2009-01-04       Impact factor: 25.606

6.  The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.

Authors:  Arianne C Richard; Cuiyan Tan; Eric T Hawley; Julio Gomez-Rodriguez; Ritobrata Goswami; Xiang-Ping Yang; Anthony C Cruz; Pallavi Penumetcha; Erika T Hayes; Martin Pelletier; Odile Gabay; Matthew Walsh; John R Ferdinand; Andrea Keane-Myers; Yongwon Choi; John J O'Shea; Aymen Al-Shamkhani; Mark H Kaplan; Igal Gery; Richard M Siegel; Françoise Meylan
Journal:  J Immunol       Date:  2015-03-18       Impact factor: 5.422

7.  Utilizing TH9 cells as a novel therapeutic strategy for malignancies.

Authors:  Yong Lu; Qing Yi
Journal:  Oncoimmunology       Date:  2013-03-01       Impact factor: 8.110

8.  Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

Authors:  Rahul Purwar; Christoph Schlapbach; Sheng Xiao; Hong Soon Kang; Wassim Elyaman; Xiaodong Jiang; Anton M Jetten; Samia J Khoury; Robert C Fuhlbrigge; Vijay K Kuchroo; Rachael A Clark; Thomas S Kupper
Journal:  Nat Med       Date:  2012-07-08       Impact factor: 53.440

9.  Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.

Authors:  Yinghua Zhao; Xiao Chu; Jintong Chen; Ying Wang; Sujun Gao; Yuxue Jiang; Xiaoqing Zhu; Guangyun Tan; Wenjie Zhao; Huanfa Yi; Honglin Xu; Xingzhe Ma; Yong Lu; Qing Yi; Siqing Wang
Journal:  Nat Commun       Date:  2016-08-05       Impact factor: 14.919

10.  OX40 signaling favors the induction of T(H)9 cells and airway inflammation.

Authors:  Xiang Xiao; Savithri Balasubramanian; Wentao Liu; Xiufeng Chu; Haibin Wang; Elizabeth J Taparowsky; Yang-Xin Fu; Yongwon Choi; Matthew C Walsh; Xian Chang Li
Journal:  Nat Immunol       Date:  2012-07-29       Impact factor: 25.606
  10 in total
  4 in total

1.  Synergistic anti-tumor effects of dasatinib and dendritic cell vaccine on metastatic breast cancer in a mouse model.

Authors:  Ningning Song; Hulin Guo; Jia Ren; Suhong Hao; Xinchao Wang
Journal:  Oncol Lett       Date:  2018-03-07       Impact factor: 2.967

2.  Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.

Authors:  Nadia Nocera Zachariah; Amrita Basu; Namrata Gautam; Ganesan Ramamoorthi; Krithika N Kodumudi; Nagi B Kumar; Loretta Loftus; Brian J Czerniecki
Journal:  Front Immunol       Date:  2021-11-24       Impact factor: 7.561

3.  Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc.

Authors:  Melissa Parny; José Bernad; Mélissa Prat; Marie Salon; Agnès Aubouy; Elsa Bonnafé; Agnès Coste; Bernard Pipy; Michel Treilhou
Journal:  Cell Biol Toxicol       Date:  2020-07-25       Impact factor: 6.691

4.  Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells.

Authors:  Jintong Chen; Yinghua Zhao; Yuxue Jiang; Sujun Gao; Yiming Wang; Dongjiao Wang; Alison Wang; Huanfa Yi; Rui Gu; Qing Yi; Siqing Wang
Journal:  Front Immunol       Date:  2018-07-31       Impact factor: 7.561
  4 in total

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