Literature DB >> 27998721

Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation.

Heather M Snyder1, Tim Ahles2, Stuart Calderwood3, Maria C Carrillo4, Honglei Chen5, Chung-Chou H Chang6, Suzanne Craft7, Philip De Jager8, Jane A Driver9, Howard Fillit10, David Knopman11, Michael Lotze12, Mary C Tierney13, Suzana Petanceska14, Andrew Saykin15, Sudha Seshadri16, Diana Shineman10, Mary Ganguli17.   

Abstract

Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion. Workshop participants outlined research focus areas, potential collaborations, and partnerships for future action.
Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Biological mechanisms; Cancer; Epidemiology; Genetics; Oncology; Repurpose therapy

Mesh：

Substances：

Year:  2016        PMID： 27998721      PMCID： PMC5548424          DOI： 10.1016/j.jalz.2016.11.002

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN： 1552-5260            Impact factor:   21.566


  63 in total

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5.  Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake.

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6.  Alzheimer disease and cancer.

Authors:  C M Roe; M I Behrens; C Xiong; J P Miller; J C Morris
Journal:  Neurology       Date:  2005-03-08       Impact factor: 9.910

Review 7.  A common biological mechanism in cancer and Alzheimer's disease?

Authors:  M I Behrens; C Lendon; C M Roe
Journal:  Curr Alzheimer Res       Date:  2009-06       Impact factor: 3.498

8.  Family history of melanoma and Parkinson disease risk.

Authors:  X Gao; K C Simon; J Han; M A Schwarzschild; A Ascherio
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9.  The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy.

Authors:  Tim A Ahles; Andrew J Saykin; Walter W Noll; Charlotte T Furstenberg; Stephen Guerin; Bernard Cole; Leila A Mott
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10.  The benefits and risks of testosterone replacement therapy: a review.

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  13 in total

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Review 2.  At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its Implications.

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Review 5.  Biological Hallmarks of Cancer in Alzheimer's Disease.

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6.  Chemotherapy and the Risk of Alzheimer's Disease in Colorectal Cancer Survivors: Evidence From the Medicare System.

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7.  Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany.

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9.  Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease.

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Review 10.  Cognitive Effects of Cancer and Cancer Treatments.

Authors:  Tim A Ahles; James C Root
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