| Literature DB >> 27997927 |
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Abstract
[This corrects the article DOI: 10.1371/journal.pone.0157435.].Entities:
Year: 2016 PMID: 27997927 PMCID: PMC5173380 DOI: 10.1371/journal.pone.0169025
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Reciprocal titres of anti-FMDV antibodies (serotype O) in sera from calves in experiment 3.
| Post-prime | Post-boost | Post-challenge | |||
|---|---|---|---|---|---|
| Group | Vaccination | Animal | PVD 14 | PVD 28 | PVD 36 |
| 1 | No vaccination (control) | C1 | - | - | 40 |
| C2 | - | - | 40 | ||
| C3 | - | - | 160 | ||
| 2 | rSFV-FMDV-P1-2A-mIRES-3C (PVD 0) + empty capsid particles (PVD 14) | C4 | - | 320 | 1280 |
| C5 | - | 40 | 320 | ||
| C6 | 20 | 320 | 1280 | ||
| 3 | empty capsid particles (PVD 0) + rSFV-FMDV-P1-2A-mIRES-3C (PVD 14) | C7 | 20 | 20 | 5120 |
| C8 | - | 80 | 5120 | ||
| C9 | - | 10 | 5120 |
Calves were either unvaccinated (group 1) or vaccinated with rSFV-FMDV-P1-2A-mIRES-3C (on PVD 0) followed by empty capsid particles (on PVD 14) (group 2) or vaccinated with empty capsids on PVD 0 and then with rSFV-FMDV-P1-2A-mIRES-3C on PVD 14 (group 3). All cattle were challenged with FMDV by needle inoculation on PVD 28. Sera collected on PVD 14, 28 (pre-challenge) and 36 were titred in the blocking ELISA using 2-fold dilutions starting at 1:5.—indicates negative.