Barbara Kraszewska-Głomba1, Agnieszka Matkowska-Kocjan2, Katarzyna Miśkiewicz3, Zofia Szymańska-Toczek4, Marta Wójcik5, Dorota Banyś6, Leszek Szenborn7. 1. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: barbara.kraszewska.glomba@gmail.com. 2. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: agnieszka.matkowska.kocjan@interia.pl. 3. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: kj.miskiewicz@gmail.com. 4. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: zofiatoczek@poczta.onet.pl. 5. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: marta.wojcik@umed.wroc.pl. 6. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: dbanys@o2.pl. 7. Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, 2-2A Chałubińskiego, 50-368 Wrocław, Poland. Electronic address: leszek.szenborn@umed.wroc.pl.
Abstract
There is no published data regarding immunologic response to vaccinations in children with PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis). The aim of this study was to evaluate mumps, measles and rubella immunity in children with PFAPA. 31 children with PFAPA syndrome and 22 healthy children (control group - CG) were recruited to the study. All children were previously vaccinated with one dose of MMR vaccine according to the Polish obligatory vaccination schedule. The patients from both groups were evaluated for anti-measles, anti-mumps and anti-rubella IgG antibodies concentrations (ELISA tests; the reference values for protective antibody levels were 150IU/L, 16RU/L and 11IU/ml respectively). The percentage of patients with protective antibodies levels was as follows: measles - 93.55% of PFAPA and 95.45% of CG patients (p=0.77); mumps - 74.19% of PFAPA and 95.45% of CG patients (p=0.02); rubella - 80.65% of PFAPA and 90.9% of CG patients (p=0.30). CONCLUSIONS: Children with PFAPA syndrome present a good response to the measles and rubella component of the MMR vaccine, however immunity against mumps after one dose of MMR may not be sufficient. Further investigation concerning immunity against vaccine-preventable diseases and the safety of vaccinations in children with periodic fever syndromes is required.
There is no published data regarding immunologic response to vaccinations in children with PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis). The aim of this study was to evaluate mumps, measles and rubella immunity in children with PFAPA. 31 children with PFAPA syndrome and 22 healthy children (control group - CG) were recruited to the study. All children were previously vaccinated with one dose of MMR vaccine according to the Polish obligatory vaccination schedule. The patients from both groups were evaluated for anti-measles, anti-mumps and anti-rubella IgG antibodies concentrations (ELISA tests; the reference values for protective antibody levels were 150IU/L, 16RU/L and 11IU/ml respectively). The percentage of patients with protective antibodies levels was as follows: measles - 93.55% of PFAPA and 95.45% of CG patients (p=0.77); mumps - 74.19% of PFAPA and 95.45% of CG patients (p=0.02); rubella - 80.65% of PFAPA and 90.9% of CG patients (p=0.30). CONCLUSIONS:Children with PFAPA syndrome present a good response to the measles and rubella component of the MMR vaccine, however immunity against mumps after one dose of MMR may not be sufficient. Further investigation concerning immunity against vaccine-preventable diseases and the safety of vaccinations in children with periodic fever syndromes is required.
Authors: Marc H Jansen; Christien Rondaan; Geertje Legger; Kirsten Minden; Yosef Uziel; Nataša Toplak; Despoina Maritsi; Mirjam van den Berg; Guy Berbers; Patricia Bruijning; Yona Egert; Christophe Normand; Marc Bijl; Helen Foster; Isabelle Kone-Paut; Carine Wouters; Angelo Ravelli; Ori Elkayam; Nicolaas M Wulffraat; Marloes W Heijstek Journal: Front Pediatr Date: 2022-07-06 Impact factor: 3.569