OBJECTIVE: Approximately 25% of women are colonized with group B streptococcus (GBS). We assessed whether body mass index (BMI) is an independent risk factor for GBS colonization. STUDY DESIGN: We performed a retrospective cohort study using a previously collected database of women who delivered singleton gestations at term. Individual patient medical record review was undertaken to add GBS-related information to the database. Univariable logistic regression was used to assess the relationship between GBS colonization and BMI. Multivariable logistic regression was used to adjust for confounders. RESULTS: A total of 2045 patients met enrollment criteria. The prevalence of GBS colonization was 29%. In the unadjusted analysis, there was a statistically significant increase in GBS colonization per unit increase in BMI (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.04). This relationship remained significant after adjusting for confounders (race, marital status, payer, chronic hypertension, concomitant genital infections) (OR 1.01, 95% CI 1.00-1.03; p = 0.04). By BMI category, there were no differences in antibiotic susceptibilities or mode of ascertainment of GBS colonization. CONCLUSION: Obesity is an independent risk factor for GBS colonization; however, this association is weak.
OBJECTIVE: Approximately 25% of women are colonized with group B streptococcus (GBS). We assessed whether body mass index (BMI) is an independent risk factor for GBS colonization. STUDY DESIGN: We performed a retrospective cohort study using a previously collected database of women who delivered singleton gestations at term. Individual patient medical record review was undertaken to add GBS-related information to the database. Univariable logistic regression was used to assess the relationship between GBS colonization and BMI. Multivariable logistic regression was used to adjust for confounders. RESULTS: A total of 2045 patients met enrollment criteria. The prevalence of GBS colonization was 29%. In the unadjusted analysis, there was a statistically significant increase in GBS colonization per unit increase in BMI (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.04). This relationship remained significant after adjusting for confounders (race, marital status, payer, chronic hypertension, concomitant genital infections) (OR 1.01, 95% CI 1.00-1.03; p = 0.04). By BMI category, there were no differences in antibiotic susceptibilities or mode of ascertainment of GBS colonization. CONCLUSION: Obesity is an independent risk factor for GBS colonization; however, this association is weak.
Entities:
Keywords:
Obesity; antibiotic prophylaxis; group B streptococcus; pregnancy
Authors: Kartik K Venkatesh; Catherine J Vladutiu; Robert A Strauss; John M Thorp; Jeffrey S A Stringer; David M Stamilio; Brenna L Hughes; Sarah Dotters-Katz Journal: J Womens Health (Larchmt) Date: 2020-05-04 Impact factor: 2.681
Authors: Alison J Eastman; Rebecca E Moore; Steven D Townsend; Jennifer A Gaddy; David M Aronoff Journal: Clin Ther Date: 2021-01-21 Impact factor: 3.393