BACKGROUND: The reported roles of matrix metalloproteinase 2 (MMP-2) on the prognosis of patients with epithelial ovarian cancers (EOCs) are inconsistent. OBJECTIVE: This meta-analysis was performed to evaluate the prognostic significance of MMP-2 for patients with EOCs by analyzing 11 studies. METHODS: We systematically searched articles in the Cochrane Library, Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Biological Medical (CBM) Database, updated to February 1st 2015, with the following search terms: ovarian neoplasm OR ovarian tumor OR ovarian carcinoma OR ovarian malignance OR ovarian cancer AND matrix metalloproteinase-2 OR MMP-2. RESULTS: A total of 11 studies involving 1058 patients with EOCs were in accordance with the inclusion criteria. The pooled HR was 1.09 (95% CI 0.32-1.86, p = 0.006) in patients with overexpression of stromal MMP-2 with significant heterogeneity (I 2 = 53.1%, p = 0.074) between studies. For patients with MMP-2 overexpression in tumor cells, the pooled HR was 1.42 (95% CI 1.14-1.70, p = 0.000) with no significant heterogeneity (I 2 = 43.4%, p = 0.078) between studies. Sensitivity analyses were stable. CONCLUSIONS: MMP-2 overexpression in tumor cells rather than stroma was significantly associated with poor prognosis in patient with endothelial ovarian cancer; however, the result remains to be confirmed with additional high-quality studies.
BACKGROUND: The reported roles of matrix metalloproteinase 2 (MMP-2) on the prognosis of patients with epithelial ovarian cancers (EOCs) are inconsistent. OBJECTIVE: This meta-analysis was performed to evaluate the prognostic significance of MMP-2 for patients with EOCs by analyzing 11 studies. METHODS: We systematically searched articles in the Cochrane Library, Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Chinese Biological Medical (CBM) Database, updated to February 1st 2015, with the following search terms: ovarian neoplasm OR ovarian tumor OR ovarian carcinoma OR ovarian malignance OR ovarian cancer AND matrix metalloproteinase-2 OR MMP-2. RESULTS: A total of 11 studies involving 1058 patients with EOCs were in accordance with the inclusion criteria. The pooled HR was 1.09 (95% CI 0.32-1.86, p = 0.006) in patients with overexpression of stromal MMP-2 with significant heterogeneity (I 2 = 53.1%, p = 0.074) between studies. For patients with MMP-2 overexpression in tumor cells, the pooled HR was 1.42 (95% CI 1.14-1.70, p = 0.000) with no significant heterogeneity (I 2 = 43.4%, p = 0.078) between studies. Sensitivity analyses were stable. CONCLUSIONS:MMP-2 overexpression in tumor cells rather than stroma was significantly associated with poor prognosis in patient with endothelial ovarian cancer; however, the result remains to be confirmed with additional high-quality studies.
Entities:
Keywords:
MMP-2; Meta-analysis; Ovarian epithelial carcinoma; Prognostic value
Authors: Flavia Morales-Vásquez; Rocío Castillo-Sánchez; María J Gómora; Miguel Ángel Almaraz; Enrique Pedernera; Delia Pérez-Montiel; Elizabeth Rendón; Horacio Noé López-Basave; Edgar Román-Basaure; Sergio Cuevas-Covarrubias; Juan Maldonado-Cubas; Antonio Villa; Carmen Mendez Journal: J Ovarian Res Date: 2020-07-28 Impact factor: 4.234
Authors: Loganathan Rangasamy; Bruno Di Geronimo; Irene Ortín; Claire Coderch; José María Zapico; Ana Ramos; Beatriz de Pascual-Teresa Journal: Molecules Date: 2019-08-16 Impact factor: 4.411
Authors: Margot De Marco; Antonia Falco; Roberta Iaccarino; Antonio Raffone; Antonio Mollo; Maurizio Guida; Alessandra Rosati; Massimiliano Chetta; Giovanni Genovese; Francesco De Caro; Mario Capunzo; Maria Caterina Turco; Vladimir N Uversky; Liberato Marzullo Journal: Br J Cancer Date: 2021-06-07 Impact factor: 9.075
Authors: Verena Hugenberg; Malte Behrends; Stefan Wagner; Sven Hermann; Michael Schäfers; Hartmuth C Kolb; Katrin Szardenings; Joseph C Walsh; Luis F Gomez; Klaus Kopka; Günter Haufe Journal: EJNMMI Radiopharm Chem Date: 2018-07-27
Authors: Alisha T Poole; Christopher A Sitko; Caitlin Le; Christian C Naus; Bryan M Hill; Eric A C Bushnell; Vincent C Chen Journal: J Enzyme Inhib Med Chem Date: 2020-12 Impact factor: 5.051