Literature DB >> 27993897

Impact of coronary heart disease on cognitive decline in Alzheimer's disease: a prospective longitudinal cohort study in primary care.

Markus Bleckwenn1, Luca Kleineidam2, Michael Wagner2, Frank Jessen3, Siegfried Weyerer4, Jochen Werle4, Birgitt Wiese5, Dagmar Lühmann6, Tina Posselt6, Hans-Helmut König7, Christian Brettschneider8, Edelgard Mösch9, Dagmar Weeg10, Angela Fuchs11, Michael Pentzek11, Tobias Luck12, Steffi G Riedel-Heller13, Wolfgang Maier14, Martin Scherer15.   

Abstract

BACKGROUND: Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. AIM: To determine whether CHD increases the speed of cognitive decline in Alzheimer's disease, and to discuss the potential for secondary cardiovascular prevention to modify this decline. DESIGN AND
SETTING: Prospective multicentre cohort study in general practices in six cities in Germany.
METHOD: Participants were patients with probable mild-to-moderate Alzheimer's dementia or mixed dementia (n = 118; mean age 85.6 [±3.4] years, range 80-96 years). The authors assessed the presence of CHD according to the family physicians' diagnosis. Cognitive performance was measured during home visits for up to 3 years in intervals of 6 months, using Mini Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB). The authors also recorded whether patients died in the observation period.
RESULTS: At baseline, 65 patients (55%) had CHD and/or a heart condition following a myocardial infarction. The presence of CHD accelerated cognitive decline (MMSE, P<0.05) by about 66%, and reduced cognitive-functional ability (CDR-SoB, P<0.05) by about 83%, but had no impact on survival.
CONCLUSION: The study shows that CHD has a significant influence on cognitive decline in older patients with late-onset dementia. The dementia process might therefore be positively influenced by cardiovascular prevention, and this possible effect should be further investigated. © British Journal of General Practice 2017.

Entities:  

Keywords:  Alzheimer’s disease; cardiovascular diseases; cardiovascular risk; cognitive decline; dementia; family practice; primary health care

Mesh:

Year:  2016        PMID: 27993897      PMCID: PMC5308117          DOI: 10.3399/bjgp16X688813

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  37 in total

1.  Heart disease and stroke statistics--2012 update: a report from the American Heart Association.

Authors:  Véronique L Roger; Alan S Go; Donald M Lloyd-Jones; Emelia J Benjamin; Jarett D Berry; William B Borden; Dawn M Bravata; Shifan Dai; Earl S Ford; Caroline S Fox; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Diane M Makuc; Gregory M Marcus; Ariane Marelli; David B Matchar; Claudia S Moy; Dariush Mozaffarian; Michael E Mussolino; Graham Nichol; Nina P Paynter; Elsayed Z Soliman; Paul D Sorlie; Nona Sotoodehnia; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner
Journal:  Circulation       Date:  2011-12-15       Impact factor: 29.690

Review 2.  Analyzing longitudinal data with missing values.

Authors:  Craig K Enders
Journal:  Rehabil Psychol       Date:  2011-10-03

3.  2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Authors:  Neil J Stone; Jennifer G Robinson; Alice H Lichtenstein; C Noel Bairey Merz; Conrad B Blum; Robert H Eckel; Anne C Goldberg; David Gordon; Daniel Levy; Donald M Lloyd-Jones; Patrick McBride; J Sanford Schwartz; Susan T Shero; Sidney C Smith; Karol Watson; Peter W F Wilson
Journal:  J Am Coll Cardiol       Date:  2013-11-12       Impact factor: 24.094

Review 4.  In-house heart-brain clinics to reduce Alzheimer's disease incidence.

Authors:  Jack C de la Torre
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

5.  Benefits of statins in elderly subjects without established cardiovascular disease: a meta-analysis.

Authors:  Gianluigi Savarese; Antonio M Gotto; Stefania Paolillo; Carmen D'Amore; Teresa Losco; Francesca Musella; Oriana Scala; Caterina Marciano; Donatella Ruggiero; Fabio Marsico; Giuseppe De Luca; Bruno Trimarco; Pasquale Perrone-Filardi
Journal:  J Am Coll Cardiol       Date:  2013-08-28       Impact factor: 24.094

Review 6.  Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases.

Authors:  Shajith Anoop; Anoop Misra; Kiran Meena; Kalpana Luthra
Journal:  Indian J Med Res       Date:  2010-10       Impact factor: 2.375

7.  [Prevalence of dementia and medical care in German nursing homes: a nationally representative survey].

Authors:  Martina Schäufele; Leonore Köhler; Ingrid Hendlmeier; Andreas Hoell; Siegfried Weyerer
Journal:  Psychiatr Prax       Date:  2013-05-13

Review 8.  Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors.

Authors:  Raj N Kalaria; Gladys E Maestre; Raul Arizaga; Robert P Friedland; Doug Galasko; Kathleen Hall; José A Luchsinger; Adesola Ogunniyi; Elaine K Perry; Felix Potocnik; Martin Prince; Robert Stewart; Anders Wimo; Zhen-Xin Zhang; Piero Antuono
Journal:  Lancet Neurol       Date:  2008-07-28       Impact factor: 44.182

Review 9.  Improved Cardiovascular Disease Outcomes in Older Adults.

Authors:  Daniel E Forman; Karen Alexander; Ralph G Brindis; Anne B Curtis; Mathew Maurer; Michael W Rich; Laurence Sperling; Nanette K Wenger
Journal:  F1000Res       Date:  2016-01-28

10.  2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).

Authors:  Giuseppe Mancia; Robert Fagard; Krzysztof Narkiewicz; Josep Redon; Alberto Zanchetti; Michael Böhm; Thierry Christiaens; Renata Cifkova; Guy De Backer; Anna Dominiczak; Maurizio Galderisi; Diederick E Grobbee; Tiny Jaarsma; Paulus Kirchhof; Sverre E Kjeldsen; Stéphane Laurent; Athanasios J Manolis; Peter M Nilsson; Luis Miguel Ruilope; Roland E Schmieder; Per Anton Sirnes; Peter Sleight; Margus Viigimaa; Bernard Waeber; Faiez Zannad; Josep Redon; Anna Dominiczak; Krzysztof Narkiewicz; Peter M Nilsson; Michel Burnier; Margus Viigimaa; Ettore Ambrosioni; Mark Caufield; Antonio Coca; Michael Hecht Olsen; Roland E Schmieder; Costas Tsioufis; Philippe van de Borne; Jose Luis Zamorano; Stephan Achenbach; Helmut Baumgartner; Jeroen J Bax; Héctor Bueno; Veronica Dean; Christi Deaton; Cetin Erol; Robert Fagard; Roberto Ferrari; David Hasdai; Arno W Hoes; Paulus Kirchhof; Juhani Knuuti; Philippe Kolh; Patrizio Lancellotti; Ales Linhart; Petros Nihoyannopoulos; Massimo F Piepoli; Piotr Ponikowski; Per Anton Sirnes; Juan Luis Tamargo; Michal Tendera; Adam Torbicki; William Wijns; Stephan Windecker; Denis L Clement; Antonio Coca; Thierry C Gillebert; Michal Tendera; Enrico Agabiti Rosei; Ettore Ambrosioni; Stefan D Anker; Johann Bauersachs; Jana Brguljan Hitij; Mark Caulfield; Marc De Buyzere; Sabina De Geest; Geneviève Anne Derumeaux; Serap Erdine; Csaba Farsang; Christian Funck-Brentano; Vjekoslav Gerc; Giuseppe Germano; Stephan Gielen; Herman Haller; Arno W Hoes; Jens Jordan; Thomas Kahan; Michel Komajda; Dragan Lovic; Heiko Mahrholdt; Michael Hecht Olsen; Jan Ostergren; Gianfranco Parati; Joep Perk; Jorge Polonia; Bogdan A Popescu; Zeljko Reiner; Lars Rydén; Yuriy Sirenko; Alice Stanton; Harry Struijker-Boudier; Costas Tsioufis; Philippe van de Borne; Charalambos Vlachopoulos; Massimo Volpe; David A Wood
Journal:  Eur Heart J       Date:  2013-06-14       Impact factor: 29.983

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  9 in total

1.  Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats.

Authors:  Ghadha Ibrahim Fouad
Journal:  Neurochem Res       Date:  2020-03-02       Impact factor: 3.996

2.  Associations between coronary heart disease and risk of cognitive impairment: A meta-analysis.

Authors:  Xuan Liang; Yilin Huang; Xu Han
Journal:  Brain Behav       Date:  2021-03-20       Impact factor: 2.708

3.  Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.

Authors:  Richard Sherva; Alden Gross; Shubhabrata Mukherjee; Ryan Koesterer; Philippe Amouyel; Celine Bellenguez; Carole Dufouil; David A Bennett; Lori Chibnik; Carlos Cruchaga; Jorge Del-Aguila; Lindsay A Farrer; Richard Mayeux; Leanne Munsie; Ashley Winslow; Stephen Newhouse; Andrew J Saykin; John S K Kauwe; Paul K Crane; Robert C Green
Journal:  Alzheimers Dement       Date:  2020-06-23       Impact factor: 16.655

4.  Metabolic Risk Factors of Alzheimer's Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study.

Authors:  Chih-Kuang Cheng; Yu-Chien Tsao; Yuan-Chih Su; Fung-Chang Sung; Hsu-Chih Tai; Woon-Man Kung
Journal:  Behav Neurol       Date:  2018-06-03       Impact factor: 3.342

Review 5.  Alzheimer's Disease and Cardiovascular Disease: A Particular Association.

Authors:  Giacomo Tini; Riccardo Scagliola; Fiammetta Monacelli; Giovanni La Malfa; Italo Porto; Claudio Brunelli; Gian Marco Rosa
Journal:  Cardiol Res Pract       Date:  2020-05-05       Impact factor: 1.866

6.  Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Authors:  Zhike Zhou; Yifan Liang; Xiaoqian Zhang; Junjie Xu; Jueying Lin; Rongwei Zhang; Kexin Kang; Chang Liu; Chuansheng Zhao; Mei Zhao
Journal:  Front Aging Neurosci       Date:  2020-01-30       Impact factor: 5.750

7.  Gender Differences in Demographic and Pharmacological Factors in Patients Diagnosed with Late-Onset of Alzheimer's Disease.

Authors:  Melissa J Bailey-Taylor; Nicolas Poupore; Laurie Theriot Roley; Richard L Goodwin; Brooks Mcphail; Thomas I Nathaniel
Journal:  Brain Sci       Date:  2022-01-26

8.  The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis.

Authors:  Congying Xia; Marleen Vonder; Grigory Sidorenkov; Matthijs Oudkerk; Jan Cees de Groot; Pim van der Harst; Geertruida H de Bock; Peter Paul De Deyn; Rozemarijn Vliegenthart
Journal:  J Atheroscler Thromb       Date:  2020-02-15       Impact factor: 4.928

9.  Voxel-based specific regional analysis system for Alzheimer's disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study.

Authors:  Yoko Ueba; Takaaki Murakami; Taizo Yamamoto; Akira Kuroe; Masahide Yamasaki; Daita Kaneda; Daisuke Otani; Sakura Kiyobayashi; Kaori Ikeda; Daisuke Yabe; Masahito Ogura; Nobuya Inagaki
Journal:  J Diabetes Investig       Date:  2021-07-17       Impact factor: 4.232

  9 in total

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