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Literature DB >> 2799384

Detection of cell-affecting agents with a silicon biosensor.

J W Parce¹, J C Owicki, K M Kercso, G B Sigal, H G Wada, V C Muir, L J Bousse, K L Ross, B I Sikic, H M McConnell.

Abstract

Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.

Entities: Chemical

Mesh：

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Year: 1989 PMID： 2799384 DOI： 10.1126/science.2799384

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

28 in total

1. Possible mechanism by which stress accelerates growth of virally derived tumors.

Authors: L M Romero; K M Raley-Susman; D M Redish; S M Brooke; H C Horner; R M Sapolsky
Journal: Proc Natl Acad Sci U S A Date: 1992-11-15 Impact factor: 11.205

2. Neuron-transistor coupling: interpretation of individual extracellular recorded signals.

Authors: Sven Ingebrandt; Chi-Kong Yeung; Michael Krause; Andreas Offenhäusser
Journal: Eur Biophys J Date: 2005-03 Impact factor: 1.733

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Journal: Cytotechnology Date: 1993-01 Impact factor: 2.058

4. Cell metabolism measurements in culture via microelectronic biosensors.

Authors: M Grattarola; S Martinoia; G Carlini; A Cambiaso; M Tedesco; M T Parodi; G Ferri
Journal: Cytotechnology Date: 1991-02 Impact factor: 2.058

5. Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.

Authors: M C Coldwell; I Boyfield; A M Brown; G Stemp; D N Middlemiss
Journal: Br J Pharmacol Date: 1999-07 Impact factor: 8.739

6. Stimulation of T cells by antigenic peptide complexed with isolated chains of major histocompatibility complex class II molecules.

Authors: B Nag; H G Wada; S V Deshpande; D Passmore; T Kendrick; S D Sharma; B R Clark; H M McConnell
Journal: Proc Natl Acad Sci U S A Date: 1993-02-15 Impact factor: 11.205

Detection of cell-affecting agents with a silicon biosensor.

1. Possible mechanism by which stress accelerates growth of virally derived tumors.

2. Neuron-transistor coupling: interpretation of individual extracellular recorded signals.

3. Early detection of cell metabolism with a silicon microsensor.

4. Cell metabolism measurements in culture via microelectronic biosensors.

5. Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.

6. Stimulation of T cells by antigenic peptide complexed with isolated chains of major histocompatibility complex class II molecules.

7. Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.

Review 8. [Microsensory systems in cell biology basic research and medical diagnostics].

9. Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2.

10. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel.