Gisela Sugranyes1, Cristina Solé-Padullés2, Elena de la Serna3, Roger Borras2, Soledad Romero3, Vanessa Sanchez-Gistau4, Clemente Garcia-Rizo4, Jose Manuel Goikolea4, Nuria Bargallo5, Dolores Moreno6, Inmaculada Baeza4, Josefina Castro-Fornieles7. 1. August Pi i Sunyer Biomedical Research Institute, Barcelona; Institute of Neuroscience, Hospital Clínic, Barcelona; Biomedical Research Networking Center Consortium. Electronic address: gernest@clinic.cat. 2. August Pi i Sunyer Biomedical Research Institute, Barcelona. 3. Institute of Neuroscience, Hospital Clínic, Barcelona; Biomedical Research Networking Center Consortium. 4. August Pi i Sunyer Biomedical Research Institute, Barcelona; Institute of Neuroscience, Hospital Clínic, Barcelona; Biomedical Research Networking Center Consortium. 5. August Pi i Sunyer Biomedical Research Institute, Barcelona; Biomedical Research Networking Center Consortium; Image Diagnosis Center, Hospital Clínic, Barcelona. 6. Biomedical Research Networking Center Consortium; Hospital General Universitario Gregorio Marañón and School of Medicine, Universidad Complutense, Madrid. 7. August Pi i Sunyer Biomedical Research Institute, Barcelona; Institute of Neuroscience, Hospital Clínic, Barcelona; Biomedical Research Networking Center Consortium; University of Barcelona.
Abstract
OBJECTIVE: Cortical surface area and thickness abnormalities have been observed in patients with schizophrenia and bipolar disorders; however, no study thus far has examined cortical morphologic measurements in children and adolescents at genetic risk for the disorders comparatively. METHOD: One hundred thirty-seven participants, including 36 offspring of patients with schizophrenia (SzO), 54 offspring of patients with bipolar disorder (BpO), and 47 offspring of community controls (CcO), 6 to 17 years old, were assessed with clinical and neuroimaging methods. Sixty-nine percent of the sample was reassessed at a 27.6-month (mean) follow-up. Cortical surface reconstruction was applied to measure cortical area and thickness using FreeSurfer; mixed-effects models were used to investigate cross-sectional and longitudinal differences in global and lobar morphologic measurements. RESULTS: The SzO group exhibited a cross-sectional decrease in global, parietal, and occipital lobe surface area compared with the CcO group, and in the occipital lobe compared with the BpO group. In the SzO group, global and parietal surface area values were inversely associated with attenuated positive and negative prodromal symptom scores. No cross-sectional differences in cortical thickness were observed. Division of the sample by pubertal status showed group-by-time interactions in the pubertal and postpubertal SzO subgroup, with less longitudinal decrease in cortical surface area and thickness than in the CcO and BpO subgroups, respectively. CONCLUSION: The SzO, but not the BpO, group was characterized by cross-sectional decreases in surface area, and this was associated with prodromal symptoms. Longitudinal changes in cortical morphology associated with risk for schizophrenia may be expressed differently according to developmental stage.
OBJECTIVE: Cortical surface area and thickness abnormalities have been observed in patients with schizophrenia and bipolar disorders; however, no study thus far has examined cortical morphologic measurements in children and adolescents at genetic risk for the disorders comparatively. METHOD: One hundred thirty-seven participants, including 36 offspring of patients with schizophrenia (SzO), 54 offspring of patients with bipolar disorder (BpO), and 47 offspring of community controls (CcO), 6 to 17 years old, were assessed with clinical and neuroimaging methods. Sixty-nine percent of the sample was reassessed at a 27.6-month (mean) follow-up. Cortical surface reconstruction was applied to measure cortical area and thickness using FreeSurfer; mixed-effects models were used to investigate cross-sectional and longitudinal differences in global and lobar morphologic measurements. RESULTS: The SzO group exhibited a cross-sectional decrease in global, parietal, and occipital lobe surface area compared with the CcO group, and in the occipital lobe compared with the BpO group. In the SzO group, global and parietal surface area values were inversely associated with attenuated positive and negative prodromal symptom scores. No cross-sectional differences in cortical thickness were observed. Division of the sample by pubertal status showed group-by-time interactions in the pubertal and postpubertal SzO subgroup, with less longitudinal decrease in cortical surface area and thickness than in the CcO and BpO subgroups, respectively. CONCLUSION: The SzO, but not the BpO, group was characterized by cross-sectional decreases in surface area, and this was associated with prodromal symptoms. Longitudinal changes in cortical morphology associated with risk for schizophrenia may be expressed differently according to developmental stage.
Authors: Montserrat Fusté; Astrid Pauls; Amanda Worker; Antje A T S Reinders; Andrew Simmons; Steven C R Williams; Josep M Haro; Kate Hazelgrove; Susan Pawlby; Susan Conroy; Costanza Vecchio; Gertrude Seneviratne; Carmine M Pariante; Mitul A Mehta; Paola Dazzan Journal: Transl Psychiatry Date: 2017-12-18 Impact factor: 7.989