| Literature DB >> 27992403 |
Daian Cheng1, Mukta Deobagkar-Lele1, Ekaterina Zvezdova2, Seeyoung Choi2, Shoji Uehara2, Delphine Baup1, Sophia C Bennett1, Katherine R Bull1, Tanya L Crockford1, Helen Ferry1, Claude Warzecha2, Marlène Marcellin3, Anne Gonzalez de Peredo3, Renaud Lesourne4, Consuelo Anzilotti1, Paul E Love2, Richard J Cornall1.
Abstract
The positive and negative selection of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is determined by different antigens is not completely understood. We found that thymocyte-selection-associated family member 2 (Themis2) increased the positive selection of B1 cells and germinal center B cells by self and foreign antigens. Themis2 lowered the threshold for B-cell activation by low-avidity, but not high-avidity, antigens. Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn and signal transducer phospholipase γ2 (PLC-γ2), and increased activation of PLC-γ2 and its downstream pathways following B cell receptor stimulation. Our findings identify a unique function for Themis2 in differential signaling and provide insight into how B cells discriminate between antigens of different quantity and quality.Entities:
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Year: 2016 PMID： 27992403 DOI： 10.1038/ni.3642
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606