| Literature DB >> 27992183 |
Meilin Zhu1, Xiaomin Zhang1, Huimin Feng1, Jiajia Dai1, Jing Li1, Qian Che1, Qianqun Gu1, Tianjiao Zhu1, Dehai Li1,2.
Abstract
Six new epipolythiodioxopiperazine (ETP) alkaloids, penicisulfuranols A-F (1-6), were isolated from the mangrove endophytic fungus Penicillium janthinellum HDN13-309. All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data and ECD calculations. They belong to the unusual family of ETPs containing sulfur atoms on both α- and β-positions of amino acid residues and a rare 1,2-oxazadecaline core moiety. In addition, compounds 1-6 also possess a rare spiro-furan ring and 1-3 showed cytotoxicity with IC50 values ranging from 0.1 to 3.9 μM.Entities:
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Year: 2016 PMID： 27992183 DOI： 10.1021/acs.jnatprod.6b00483
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050