Literature DB >> 27990673

Trichodysplasia Spinulosa in a 7-Year-Old Boy Managed Using Physical Extraction of Keratin Spicules.

Michael Barton1, Suing Lockhart2, Robert Sidbury2, Richard Wang3, Heather Brandling-Bennett2.   

Abstract

Trichodysplasia spinulosa (TS) is an uncommon skin disease characterized by a folliculocentric papular eruption and keratin spine formation, classically appearing on the central face and ears. It occurs in immunosuppressed patients and is linked to a viral etiology. Diagnostic tests including polymerase chain reaction (PCR) are available for detection of the TS-associated polyomavirus. Effective treatment options include topical cidofovir and oral valganciclovir. We present a case diagnosed using PCR with skin scrapings and treated using physical extraction of the keratin spicules. Significant improvement was noted, suggesting a safe, cost-effective treatment alternative.
© 2016 Wiley Periodicals, Inc.

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Year:  2016        PMID: 27990673      PMCID: PMC5788291          DOI: 10.1111/pde.13045

Source DB:  PubMed          Journal:  Pediatr Dermatol        ISSN: 0736-8046            Impact factor:   1.588


  15 in total

1.  Development of trichodysplasia spinulosa: case report of a patient with Gorlin syndrome treated with vismodegib.

Authors:  Justin D Richey; Thomas A Graham; Terrence Katona; Jeffrey B Travers
Journal:  JAMA Dermatol       Date:  2014-09       Impact factor: 10.282

2.  Trichodysplasia Spinulosa in a 20-Month-Old Girl With a Good Response to Topical Cidofovir 1%.

Authors:  Raquel Santesteban; Marta Feito; Ander Mayor; María Beato; Esther Ramos; Raúl de Lucas
Journal:  Pediatrics       Date:  2015-12       Impact factor: 7.124

Review 3.  Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus.

Authors:  Mark R Matthews; Richard C Wang; Robert L Reddick; Victor A Saldivar; John C Browning
Journal:  J Cutan Pathol       Date:  2011-01-19       Impact factor: 1.587

4.  Viral-associated trichodysplasia: characterization of a novel polyomavirus infection with therapeutic insights.

Authors:  Karolyn A Wanat; Phillip D Holler; Tzvete Dentchev; Kenneth Simbiri; Erle Robertson; John T Seykora; Misha Rosenbach
Journal:  Arch Dermatol       Date:  2012-02

5.  Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient.

Authors:  Els van der Meijden; René W A Janssens; Chris Lauber; Jan Nico Bouwes Bavinck; Alexander E Gorbalenya; Mariet C W Feltkamp
Journal:  PLoS Pathog       Date:  2010-07-29       Impact factor: 6.823

6.  Ultrastructural and molecular confirmation of the trichodysplasia spinulosa-associated polyomavirus in biopsies of patients with trichodysplasia spinulosa.

Authors:  Zendee Elaba; Lauren Hughey; Tatyana Isayeva; Beth Weeks; Caius Solovan; Laura Solovastru; Aleodor Andea
Journal:  J Cutan Pathol       Date:  2012-08-09       Impact factor: 1.587

7.  Viral-associated trichodysplasia in patients who are immunocompromised.

Authors:  Leonard C Sperling; Maria-Magdalena Tomaszewski; Douglas A Thomas
Journal:  J Am Acad Dermatol       Date:  2004-02       Impact factor: 11.527

8.  Trichodysplasia of immunosuppression treated with oral valganciclovir.

Authors:  Aton M Holzer; Lauren C Hughey
Journal:  J Am Acad Dermatol       Date:  2009-01       Impact factor: 11.527

9.  Viral-associated trichodysplasia in a patient with lymphoma: a case report and review.

Authors:  Sandra S Osswald; Kevin B Kulick; Maria-Magdalena Tomaszewski; Leonard C Sperling
Journal:  J Cutan Pathol       Date:  2007-09       Impact factor: 1.587

10.  New findings about trichodysplasia spinulosa-associated polyomavirus (TSPyV)--novel qPCR detects TSPyV-DNA in blood samples.

Authors:  Paulo R Urbano; Luiz H S Nali; Camila S Bicalho; Ligia C Pierrotti; Elias David-Neto; Cláudio S Pannuti; Camila M Romano
Journal:  Diagn Microbiol Infect Dis       Date:  2015-10-21       Impact factor: 2.803

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  2 in total

Review 1.  The Biology and Clinical Features of Cutaneous Polyomaviruses.

Authors:  Khang D Nguyen; Bahir H Chamseddin; Clay J Cockerell; Richard C Wang
Journal:  J Invest Dermatol       Date:  2018-11-22       Impact factor: 8.551

2.  Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa-associated polyomavirus in skin, serum, and urine.

Authors:  Bahir H Chamseddin; Bao Anh Patrick D Tran; Eunice E Lee; Diana V Pastrana; Christopher B Buck; Richard C Wang; Anna Yasmine Kirkorian
Journal:  Pediatr Dermatol       Date:  2019-06-12       Impact factor: 1.997

  2 in total

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