Xilong Cui1, Wenbin Guo1, Yi Wang2, Tian-Xiao Yang2, Xin-Hua Yang3, Yefei Wang4, Jingbo Gong4, Changlian Tan1, Guangrong Xie5. 1. Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. 2. Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. 3. Institute of Education, Hunan Agricultural University, Changsha, Hunan, China. 4. Department of Applied Psychology, Hunan University of Chinese Medicine, Changsha, Hunan, China. 5. Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China. Electronic address: xiegrpsy@126.com.
Abstract
BACKGROUND: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. METHODS: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method. RESULTS: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/TP). The abnormal NH of this region and clinical characteristics were not correlated. CONCLUSION: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder.
BACKGROUND:Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. METHODS: A total of 33 first-episode, treatment-naive melancholic MDDpatients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method. RESULTS: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/TP). The abnormal NH of this region and clinical characteristics were not correlated. CONCLUSION: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder.
Authors: Yi Du; Jingjie Zhao; Yongzhi Wang; Yu Han; Ligang Deng; Hongxiao Jia; Yuan Zhou; Joyce Su; Li Li Journal: Evid Based Complement Alternat Med Date: 2020-02-18 Impact factor: 2.629