| Literature DB >> 27989141 |
Lee Faulkner1, Xiaoli Meng1, Dean J Naisbitt1, Colin F Spraggs2, B Kevin Park1.
Abstract
It is hypothesized that lapatinib-induced liver injury is caused by HLA-mediated antigen presentation to CD4 positive T cells. However, analysis of PBMC and cloned T-cells from patients with HLA-DRB1*07:01-restricted lapatinib-induced liver injury revealed no evidence for drug-specific activation. T cells were exposed to lapatinib, the M11 aldehyde, and quinone imine [oxidized form of hydroquinone amine M1] metabolites. Reactivity of the quinone imine was confirmed by mass spectrometry.Entities:
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Year: 2016 PMID： 27989141 DOI： 10.1021/acs.chemrestox.6b00400
Source DB: PubMed Journal: Chem Res Toxicol ISSN： 0893-228X Impact factor: 3.739