Fabrication of chitosan-polycaprolactone composite nanofibrous scaffold for simultaneous delivery of ferulic acid and resveratrol.

Wound healing is a complex cellular process involving various mechanisms making it intricate for designing a scaffold for therapeutic use. This study deals with the designing and development of coaxial electrospun Chitosan-Polycaprolactone nanofiber wound dressings for efficient simultaneous drug delivery. Ferulic acid and resveratrol were chosen for incorporation into core-shell nanofibers for their efficacy in anti-inflammatory and pro-angiogenic activities respectively. Structural and physico-chemical characterization of the scaffold confirmed the encapsulation of both the molecules. The in vitro release studies showed sustained release of both resveratrol and ferulic acid up to 48% and 55% respectively till 120h. Functional characterization of the nanofibrous wound dressing exhibited good in vitro and in vivo biocompatibility. The scaffold treated rats exhibited complete healing in 15days in comparison to the controls that healed in 20days. The study therefore, opens up venues for designing sequential and sustained drug delivery systems in wound therapeutics.