Development of novel electrochemical sensor on the base of molecular imprinted polymer decorated on SiC nanoparticles modified glassy carbon electrode for selective determination of loratadine.

A novel and selective electrochemical sensor was successfully developed for the determination of loratadine by drop coating of synthesized loratadine molecularly imprinted polymers on the surface of glassy carbon electrode modified with silicon carbide nanoparticles. The performance of the constructed sensor was evaluated by cyclic voltammetry, scanning electron microscopy, and electrochemical impedance spectroscopy techniques. Under optimized conditions, the resulting calibration curve exhibited a linear response within a concentration range of 1-33μM with a low detection limit (S/N=3) of 0.15μM. Finally, the proposed method was successfully applied as a selective, stabile, sensitive, simple, reproducibility electrochemical sensor with good repeatability for the determination of loratadine in real samples and satisfactory results were obtained.