| Literature DB >> 27986464 |
Jie Chen1, Yan Li1, Qiupeng Zheng2, Chunyang Bao1, Jian He1, Bin Chen1, Dongbin Lyu1, Biqiang Zheng1, Yu Xu1, Ziwen Long1, Ye Zhou1, Huiyan Zhu1, Yanong Wang1, Xianghuo He1, Yingqiang Shi3, Shenglin Huang4.
Abstract
Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. Our findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC.Entities:
Keywords: Circular RNA; Gastric cancer; Non-coding RNA; Prognosis; circPVT1
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Year: 2016 PMID： 27986464 DOI： 10.1016/j.canlet.2016.12.006
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679