| Literature DB >> 27986080 |
Arbi Pecani1, Cristiano Alessandri2, Francesca Romana Spinelli1, Roberta Priori1, Valeria Riccieri1, Manuela Di Franco1, Fulvia Ceccarelli1, Tania Colasanti1, Monica Pendolino1, Riccardo Mancini1, Simona Truglia1, Cristiana Barbati1, Marta Vomero1, Danilo Sabatinelli1, Francesca Morello1, Guido Valesini1, Fabrizio Conti1.
Abstract
RESULTS: Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were detected in 33 patients (16.5%), ACPA in 29 patients (14.5%) and RF in 64 patients (32%). In particular, 16.8% of patients with systemic lupus erythematosus and 31.1% of patients with Sjögren syndrome were positive for anti-CarP. The sensitivity of anti-CarP, ACPA and RF was 46.8, 61.8 and 64.4%, respectively and specificity was 91.95, 89.93 and 76.51%, respectively.Entities:
Year: 2016 PMID: 27986080 PMCID: PMC5159989 DOI: 10.1186/s13075-016-1205-9
Source DB: PubMed Journal: Arthritis Res Ther ISSN: 1478-6354 Impact factor: 5.156
Prevalence of anti-CarP, ACPA and RF in RA patients, disease controls and healthy subjects
| Disease | Anti-CarP positive n, (%) | ACPA positive n, (%) | RF positive n, (%) |
|---|---|---|---|
| RA (309) | 117 (37.9) | 190 (61.4) | 202 (65.3) |
| NHS (98) | 2 (2.04) | 1 (1.02) | 3 (3.06) |
| SLE (83) | 14 (16.8) | 15 (18.07) | 19 (22.8) |
| SS (45) | 14 (31.1) | 11 (24.4) | 23 (51.1) |
| SSc (51) | 3 (5.8) | 1 (1.9) | 18 (35.2) |
| OP (21) | 2 (9.5) | 2 (9.5) | 4 (19.04) |
Anti-CarP anti-carbamylated proteins antibodies, ACPA anti-citrullinated peptides antibodies, RF rheumatoid factor, RA Rheumatoid Arthritis, NHS Normal Healthy Subjects, SLE Systemic Lupus Erythematosus, SS Sjögren Syndrome, SSc Systemic Sclerosis, OP osteoporosis