| Literature DB >> 27984715 |
Jorge Iván Castillo-Quan1, T Keith Blackwell2.
Abstract
In this issue of Cell, Wu et al. employed C. elegans and human cell experiments to identify a pathway through which metformin increases lifespan and inhibits growth. A key transcriptional target, ACAD10, is activated when metformin induces nuclear exclusion of the GTPase RagC, thereby inhibiting mTORC1 through an unexpected mechanism.Entities:
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Year: 2016 PMID： 27984715 DOI： 10.1016/j.cell.2016.11.058
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582