Literature DB >> 27984654

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

M V Varma1, A F El-Kattan2, B Feng1, S J Steyn2, T S Maurer2, D O Scott2, A D Rodrigues1, L M Tremaine1.   

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Year:  2017        PMID： 27984654     DOI： 10.1002/cpt.595

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


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  5 in total

1.  Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches.

Authors:  Yingying Guo; Xiaoyan Chu; Neil J Parrott; Kim L R Brouwer; Vicky Hsu; Swati Nagar; Pär Matsson; Pradeep Sharma; Jan Snoeys; Yuichi Sugiyama; Daniel Tatosian; Jashvant D Unadkat; Shiew-Mei Huang; Aleksandra Galetin
Journal:  Clin Pharmacol Ther       Date:  2018-09-12       Impact factor: 6.875

2.  Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research.

Authors:  Na Li; Akshay Badrinarayanan; Kazuya Ishida; Xingwen Li; John Roberts; Shuai Wang; Mike Hayashi; Anshul Gupta
Journal:  AAPS J       Date:  2020-11-16       Impact factor: 4.009

3.  Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3.

Authors:  Sînziana Cristea; Elke H J Krekels; Karel Allegaert; Peter De Paepe; Annick de Jaeger; Pieter De Cock; Catherijne A J Knibbe
Journal:  AAPS J       Date:  2021-05-04       Impact factor: 4.009

4.  Identification and Evaluation of Clinical Substrates of Organic Anion Transporting Polypeptides 1B1 and 1B3.

Authors:  Savannah J McFeely; Tasha K Ritchie; Jingjing Yu; Anna Nordmark; René H Levy; Isabelle Ragueneau-Majlessi
Journal:  Clin Transl Sci       Date:  2019-03-12       Impact factor: 4.689

5.  Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.

Authors:  Chester Costales; Jian Lin; Emi Kimoto; Shinji Yamazaki; James R Gosset; A David Rodrigues; Sarah Lazzaro; Mark A West; Michael West; Manthena V S Varma
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2021-07-20
  5 in total

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