| Literature DB >> 27984105 |
Florina Teodorescu1, Yavuz Oz2, Gurvan Quéniat3, Amar Abderrahmani4, Catherine Foulon5, Marie Lecoeur5, Rana Sanyal6, Amitav Sanyal7, Rabah Boukherroub1, Sabine Szunerits8.
Abstract
On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its hybridization with therapeutics. In this work, we describe the formulation of rGO impregnated poly(ethylene glycol) dimethacrylate based hydrogels (PEGDMA-rGO) and their efficient loading with insulin. Near-infrared (NIR) light induced heating of the PEGDMA-rGO hydrogels allows for highly efficient insulin release. Most importantly, we validate that the NIR irradiation of the hydrogel has no effect on the biological and metabolic activities of the released insulin. The ease of insulin loading/reloading makes this photothermally triggered release strategy of interest for diabetic patients. Additionally, the rGO-based protein releasing platform fabricated here can be expanded towards 'on demand' release of various other therapeutically relevant biomolecules.Entities:
Keywords: Hydrogel; Insulin; Photothermal; Reduced graphene oxide; Release
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Year: 2016 PMID： 27984105 DOI： 10.1016/j.jconrel.2016.10.028
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776