Seon-Cheol Park1, Jae-Min Kim2, Tae-Youn Jun3, Min-Soo Lee4, Jung-Bum Kim5, Hyeon-Woo Yim6, Yong Chon Park7. 1. a Department of Psychiatry , Inje University Haeundae Paik Hospital , Busan , Republic of Korea. 2. b Department of Psychiatry , Chonnam National University School of Medicine , Gwangju , Republic of Korea. 3. c Department of Psychiatry , Catholic University of Korea College of Medicine , Seoul , Republic of Korea. 4. d Department of Psychiatry , Korea University College of Medicine , Seoul , Republic of Korea. 5. e Department of Psychiatry , Keimyung University School of Medicine , Daegu , Republic of Korea. 6. f Department of Preventive Medicine , Catholic University of Korea College of Medicine , Seoul , Republic of Korea. 7. g Department of Psychiatry , Hanyang University Guri Hospital , Guri , Republic of Korea.
Abstract
BACKGROUND: The polythetic nature of major depressive disorder (MDD) in DSM- IV and DSM-5 inevitably leads to diagnostic heterogeneity. AIMS: This study aimed to identify the number of depressive symptom combinations actually fulfilling the DSM-IV diagnostic criteria that can be found in Korean MDD patients and the relative frequencies of each combination. METHODS: Using the data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we enrolled 853 MDD patients diagnosed using DSM-IV and scored as 8 or more on the Hamilton Depression Rating Scale (HAMD). Descriptive statistical analyses were performed to reveal the degree of diagnostic heterogeneity of the MDD. RESULTS: This study identified 119 different depressive symptom combinations. The most common combination consisted of all nine depressive symptom profiles, and nine different combinations were each present in more than 3% of the patients. CONCLUSION: The findings support the criticism that the diagnosis of MDD is not based on a single mental process, but on a set of 'family resemblances'.
BACKGROUND: The polythetic nature of major depressive disorder (MDD) in DSM- IV and DSM-5 inevitably leads to diagnostic heterogeneity. AIMS: This study aimed to identify the number of depressive symptom combinations actually fulfilling the DSM-IV diagnostic criteria that can be found in Korean MDDpatients and the relative frequencies of each combination. METHODS: Using the data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we enrolled 853 MDDpatients diagnosed using DSM-IV and scored as 8 or more on the Hamilton Depression Rating Scale (HAMD). Descriptive statistical analyses were performed to reveal the degree of diagnostic heterogeneity of the MDD. RESULTS: This study identified 119 different depressive symptom combinations. The most common combination consisted of all nine depressive symptom profiles, and nine different combinations were each present in more than 3% of the patients. CONCLUSION: The findings support the criticism that the diagnosis of MDD is not based on a single mental process, but on a set of 'family resemblances'.
Entities:
Keywords:
Major depressive disorder; depressive symptom combinations; diagnostic heterogeneity; family resemblances; polythetic definition
Authors: Christopher R Brydges; Sudeepa Bhattacharyya; Siamak Mahmoudian Dehkordi; Yuri Milaneschi; Brenda Penninx; Rick Jansen; Bruce S Kristal; Xianlin Han; Matthias Arnold; Gabi Kastenmüller; Mandakh Bekhbat; Helen S Mayberg; W Edward Craighead; A John Rush; Oliver Fiehn; Boadie W Dunlop; Rima Kaddurah-Daouk Journal: Brain Behav Immun Date: 2022-02-04 Impact factor: 19.227