Norziah M Hani1, Amir E Torkamani1, Mohammad H Azarian2, Kamil Wa Mahmood2, Siti Hawa Ngalim3. 1. Food Technology Department, School of Industrial Technology, Universiti Sains Malaysia, Minden, Penang, Malaysia. 2. School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia. 3. Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Bertam, Penang, Malaysia.
Abstract
BACKGROUND: Drumstick (Moringa oleifera) leaves have been used as a folk herbal medicine across many cultures since ancient times. This is most probably due to presence of phytochemicals possessing antioxidant properties, which could retard oxidative stress, and their degenerative effect. The current study deals with nanoencapsulation of Moringa oleifera (MO) leaf ethanolic extract within fish sourced gelatine matrix using electrospinning technique. RESULTS: The total phenolic and flavonoid content, radical scavenging (IC50 ) and metal reducing properties were 67.0 ± 2.5 mg GAE g-1 sample 32.0 ± 0.5 mg QE g-1 extract, 0.08 ± 0.01 mg mL-1 and 510 ± 10 µmol eq Fe(II) g-1 extract, respectively. Morphological and spectroscopic analysis of the fibre mats confirmed successful nanoencapsulation of MO extract within defect free nanofibres via electrospinning process. The percentage encapsulation efficiency (EE) was between 80% and 85%. Furthermore, thermal stability of encapsulated fibres, especially at 3% and 5% of core loading content, was significantly improved. Toxicological analysis revealed that the extract in its original and encapsulated form was safe for oral consumption. CONCLUSION: Overall, the present study showed the potential of ambient temperature electrospinning process as a safe nanoencapsulation method, where MO extract retained its antioxidative capacities.
BACKGROUND: Drumstick (Moringa oleifera) leaves have been used as a folk herbal medicine across many cultures since ancient times. This is most probably due to presence of phytochemicals possessing antioxidant properties, which could retard oxidative stress, and their degenerative effect. The current study deals with nanoencapsulation of Moringa oleifera (MO) leaf ethanolic extract within fish sourced gelatine matrix using electrospinning technique. RESULTS: The total phenolic and flavonoid content, radical scavenging (IC50 ) and metal reducing properties were 67.0 ± 2.5 mg GAE g-1 sample 32.0 ± 0.5 mg QE g-1 extract, 0.08 ± 0.01 mg mL-1 and 510 ± 10 µmol eq Fe(II) g-1 extract, respectively. Morphological and spectroscopic analysis of the fibre mats confirmed successful nanoencapsulation of MO extract within defect free nanofibres via electrospinning process. The percentage encapsulation efficiency (EE) was between 80% and 85%. Furthermore, thermal stability of encapsulated fibres, especially at 3% and 5% of core loading content, was significantly improved. Toxicological analysis revealed that the extract in its original and encapsulated form was safe for oral consumption. CONCLUSION: Overall, the present study showed the potential of ambient temperature electrospinning process as a safe nanoencapsulation method, where MO extract retained its antioxidative capacities.
Authors: Manar A Eissa; Yumi Z H-Y Hashim; Mohd Hamzah Mohd Nasir; Yusilawati Ahmad Nor; Hamzah Mohd Salleh; Muhammad Lokman Md Isa; Saripah S S Abd-Azziz; Nor Malia Abd Warif; Eman Ramadan; Noha M Badawi Journal: Drug Deliv Date: 2021-12 Impact factor: 6.819
Authors: Danya Elizabeth Estrella-Osuna; José Agustín Tapia-Hernández; Saúl Ruíz-Cruz; Enrique Márquez-Ríos; José de Jesús Ornelas-Paz; Carmen Lizette Del-Toro-Sánchez; Víctor Manuel Ocaño-Higuera; Francisco Rodríguez-Félix; María Isabel Estrada-Alvarado; Luis Alberto Cira-Chávez Journal: Nanomaterials (Basel) Date: 2022-07-04 Impact factor: 5.719