Johannes H Proost1,2. 1. Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands. j.h.proost@rug.nl. 2. Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. j.h.proost@rug.nl.