| Literature DB >> 27981487 |
Xing Rong1, Lianhong Jia2, Lanlan Hong1, Lulu Pan1, Xiangyang Xue3, Chunxiang Zhang4, Jiacheng Lu5, Zengyou Jin5, Huixian Qiu1, Rongzhou Wu6, Maoping Chu7.
Abstract
Recent studies have suggested that serum microRNAs (miRNAs) are novel biomarkers for many cardiovascular diseases, but their role in Kawasaki disease (KD) is still unclear. We demonstrated that serum miR-92a-3p levels were significantly higher in children with KD compared with children with fever and controls (both P < 0.05). When the disease recovered, miR-92a-3p levels returned to those of controls. Clinical and pathological data showed that high levels of miR-92a-3p were significantly associated with coronary artery lesions (CALs). Analysis of the receiver operating characteristic (ROC) curve showed that serum miR-92a-3p had a sensitivity of 81.8% and a specificity of 66.7% for distinguishing KD with CALs from KD without CALs. The area under the curve was 0.816 (P < 0.05, 95% CI 0.669-0.962). Therefore, the miRNA miR-92a-3p may be used as a potential biomarker for diagnosis of KD and KD with coronary artery lesions.Entities:
Keywords: Biomarker; Coronary artery lesion; Kawasaki disease; MicroRNA
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Year: 2016 PMID： 27981487 DOI： 10.1007/s12265-016-9717-x
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132