| Literature DB >> 27981414 |
Wu Xiaoyan1,2,3, Eva Maria Arriero Pais1,2,3, Li Lan1,2,3, Chen Jingrui1,2,3, Miao Lin1,2,3, Patrick Asare Fordjour1,2,3, Fan Guanwei4,5,6,7.
Abstract
An increasing number of diseases are being newly closely associated with inflammation, where microRNAs seem to play a critical role in the whole disease process from initiation to development. MicroRNAs are small non-coding RNAs that govern gene expression and modulation by means of mRNA degradation or translational repression. After several profound research studies, new correlations between microRNA-155 and inflammation-related diseases are strongly emerging. Hence, we review in this paper the possible molecular mechanisms of microRNA-155 in inflammatory disorders. Furthermore, we also consider the feasibility of targeting it as a bright alternative to improve the early diagnose statistics and treatments in those diseases. MicroRNA-155 features a novel breakthrough in fine-tuning inflammatory responses and, thereby, in treating a wide spectrum of diseases with inflammation as a common denominator.Entities:
Keywords: diagnosis and treatment of inflammatory diseases; inflammation; mechanism of action; microRNA-155
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Year: 2017 PMID： 27981414 DOI： 10.1007/s10753-016-0488-y
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092