| Literature DB >> 27981392 |
Jing Sun1, Juan Du1, Wei Feng1, Boyao Lu2, Hongrui Liu1, Jie Guo1, Norio Amizuka3, Minqi Li4.
Abstract
This study evaluated the effects of metformin on orthodontic tooth movement in a rat model of type 2 diabetes mellitus. Rats were fed a high-fat diet for 4 weeks to induce fat accumulation and insulin resistance, and then injected with a low dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetes. An orthodontic appliance was placed in normoglycemic, type 2 diabetes, and type 2 diabetes with metformin-administrated rats. After 14 days, type 2 diabetes rats exhibited greater orthodontic tooth movement and had a higher number of tartrate-resistant acid phosphatase-positive osteoclasts, stronger cathepsin K expression, and weaker alkaline phosphatase immunostaining than normoglycemic rats. Metformin administration resulted in normalization of osteoclast numbers, cathepsin K immunostaining, and of tooth movement as well as partly recovery of alkaline phosphatase expression in diabetic rats. Metformin also reduced sclerostin expression and improved the immunolocalization of dentin matrix protein 1 in osteocytes of type 2 diabetes rats. These results suggest that metformin administration reversed the adverse effects of diabetes on orthodontic tooth movement.Entities:
Keywords: Dentin matrix protein 1; Diabetes; Metformin; Orthodontic tooth movement; Sclerostin
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Year: 2016 PMID： 27981392 DOI： 10.1007/s10735-016-9707-y
Source DB: PubMed Journal: J Mol Histol ISSN： 1567-2379 Impact factor: 2.611