| Literature DB >> 27979364 |
Raphaël Colle1, Romain Cohen2, Delphine Cochereau3, Alex Duval4, Olivier Lascols5, Daniel Lopez-Trabada1, Pauline Afchain1, Isabelle Trouilloud1, Yann Parc6, Jérémie H Lefevre6, Jean-François Fléjou7, Magali Svrcek7, Thierry André8.
Abstract
Microsatellite instability (MSI) is a tumor phenotype linked to somatic or germline (Lynch syndrome) inactivating alterations of DNA mismatch repair genes. A broad spectrum of neoplasms exhibits MSI phenotype, mainly colorectal cancer, endometrial cancer, and gastric cancer. MSI tumors are characterized by dense immune infiltration and high load of tumor neo-antigens. Growing evidence is accumulating on the efficacy of immune checkpoint inhibition for patients treated for MSI solid tumors. We present a comprehensive overview of MSI phenotype, its biological landscape and current diagnostic methods. Then we focus on MSI as a predictive biomarker of response to immune checkpoint inhibition in the context of colorectal cancer and non-colorectal tumors.Entities:
Keywords: Cancer colorectal; Cancer de l’endomètre; Checkpoint immunitaires; Colorectal cancer; Déficience du système de réparation de l’ADN; Endometrial cancer; Immune checkpoint; Lynch syndrome; Mismatch repair deficiency; Nivolumab; Syndrome de Lynch
Mesh：
Year: 2016 PMID： 27979364 DOI： 10.1016/j.bulcan.2016.11.006
Source DB: PubMed Journal: Bull Cancer ISSN： 0007-4551 Impact factor: 1.276