Literature DB >> 27978791

Exercise Prevents Cognitive Function Decline and Demyelination in the White Matter of APP/PS1 Transgenic AD Mice.

Lei Zhang1, Feng-Lei Chao1, Yan-Min Luo1, Qian Xiao1, Lin Jiang2, Chun-Ni Zhou2, Yi Zhang2, Fu-Lin Lv2, Qi He2, Jing Ma2, Yong Tang3.   

Abstract

BACKGROUND: Whether exercise could delay the cognitive function decline and structural changes in Alzheimer's disease (AD) are not fully understood.
METHODS: 6-month-old male APP/PS1 double transgenic mice ran four months and then the effects of exercise on the cognitive function and the white matter of AD were investigated.
RESULTS: The mean escape latency of the excercised group was significantly shortened when compared to that of the sedentary group. The percentage of time in target quadrant and the target zone frequency of the exercised group were significantly increased when compared to the sedentary group. The white matter volume, the myelinated fiber volume and axon volume in the white matter of the exercised group were significantly increased when compared to the sedentary group.
CONCLUSION: Exercise could improve the cognitive function in AD, and the effects of exercise on the white matter of AD might be one of the structural bases for the protective effect of exercise on the cognitive function of AD. The exercise-induced protection of the white matter in AD might be due to the fact that the exercise prevented the demyelination of the myelinated fibers in the white matter of AD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Alzheimer's disease; White matter; exercise; myelinated fiber; stereology; transgenic mice

Mesh：

Substances：

Year:  2017        PMID： 27978791     DOI： 10.2174/1567205014666161213121353

Source DB:  PubMed          Journal:  Curr Alzheimer Res        ISSN： 1567-2050            Impact factor:   3.498


  10 in total

1.  Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.

Authors:  Nicole C Berchtold; G Aleph Prieto; Michael Phelan; Daniel L Gillen; Pierre Baldi; David A Bennett; Aron S Buchman; Carl W Cotman
Journal:  Neurobiol Aging       Date:  2019-02-20       Impact factor: 4.673

2.  Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion.

Authors:  Ryo Ohtomo; Keita Kinoshita; Gaku Ohtomo; Hajime Takase; Gen Hamanaka; Kazuo Washida; Mohammad Rashedul Islam; Christiane D Wrann; Hiroshi Katsuki; Atsushi Iwata; Josephine Lok; Eng H Lo; Ken Arai
Journal:  Transl Stroke Res       Date:  2019-10-12       Impact factor: 6.829

Review 3.  Bridging the Gap: A Geroscience Primer for Neuroscientists With Potential Collaborative Applications.

Authors:  Jessica M Hoffman; Caesar M Hernandez; Abbi R Hernandez; Jennifer L Bizon; Sara N Burke; Christy S Carter; Thomas W Buford
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2022-01-07       Impact factor: 6.591

4.  Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice.

Authors:  Chun-Ni Zhou; Feng-Lei Chao; Yi Zhang; Lin Jiang; Lei Zhang; Yan-Min Luo; Qian Xiao; Lin-Mu Chen; Yong Tang
Journal:  Front Aging Neurosci       Date:  2018-08-17       Impact factor: 5.750

5.  Effects of an Exercise Program Combining Aerobic and Resistance Training on Protein Expressions of Neurotrophic Factors in Obese Rats Injected with Beta-Amyloid.

Authors:  Gyuho Lee; Yunwook Kim; Jung-Hee Jang; Chan Lee; Jaewoo Yoon; Nayoung Ahn; Kijin Kim
Journal:  Int J Environ Res Public Health       Date:  2022-06-28       Impact factor: 4.614

6.  Disrupted myelination network in the cingulate cortex of Parkinson's disease.

Authors:  Song Xie; Jiajun Yang; Shenghui Huang; Yuanlan Fan; Tao Xu; Jiangshuang He; Jiahao Guo; Xiang Ji; Zhibo Wang; Peijun Li; Jiangfan Chen; Yi Zhang
Journal:  IET Syst Biol       Date:  2022-04-08       Impact factor: 1.468

7.  Effects of exercise on capillaries in the white matter of transgenic AD mice.

Authors:  Yi Zhang; Feng-Lei Chao; Chun-Ni Zhou; Lin Jiang; Lei Zhang; Lin-Mu Chen; Yan-Min Luo; Qian Xiao; Yong Tang
Journal:  Oncotarget       Date:  2017-07-22

Review 8.  Molecular Mechanisms of Oligodendrocyte Regeneration in White Matter-Related Diseases.

Authors:  Ryo Ohtomo; Atsushi Iwata; Ken Arai
Journal:  Int J Mol Sci       Date:  2018-06-12       Impact factor: 5.923

9.  A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer's disease.

Authors:  Kaja Falkenhain; Nancy E Ruiz-Uribe; Mohammad Haft-Javaherian; Muhammad Ali; Pietro E Michelucci; Chris B Schaffer; Oliver Bracko
Journal:  PLoS One       Date:  2020-08-28       Impact factor: 3.240

10.  Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats.

Authors:  Lin Chen; Feng-Lei Chao; Wei Lu; Lei Zhang; Chun-Xia Huang; Shu Yang; Xuan Qiu; Hao Yang; Yuan-Yu Zhao; San-Rong Wang; Chen Li; Yong Tang
Journal:  Front Aging Neurosci       Date:  2020-10-23       Impact factor: 5.750
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.