| Literature DB >> 27978671 |
Xing-De Wu1, Dan Luo1, Wen-Chao Tu1, Zhen-Tao Deng1, Xue-Jiao Chen1, Jia Su1, Xu Ji1, Qin-Shi Zhao1.
Abstract
Three rearranged labdane-type diterpenoids, hypophyllins A-C (1-3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.13,7]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of Hypoestes phyllostachya "Rosea". The absolute configurations of 1-4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1-4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.Entities:
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Year: 2016 PMID： 27978671 DOI： 10.1021/acs.orglett.6b03388
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005