PURPOSE: To describe the clinical features and outcomes of patients with stage III or IV retinoblastoma. METHODS: This was a retrospective study of 80 patients. RESULTS: Based on the International Retinoblastoma Staging System (IRSS), the tumors (n = 81) belonged to stage IIIa (n = 38, 47%), IIIb (n = 1, 1%), IVa2 (n = 10, 12%), IVb1 (n = 14, 17%), and IVb3 (n = 18, 22%). Of 80 patients, 42 (53%) were compliant to treatment and 38 (47%) were non-compliant. All 38 patients who were non-compliant to treatment died of the disease at a mean duration of 13 months from diagnosis. Of the 42 patients compliant to treatment, 22 (52%) died before completion of treatment. Twenty patients with stage III disease (25%) could complete the multimodal treatment and 17 (71%) were alive and well at a median follow-up duration of 77 months. CONCLUSIONS: Compliant multimodality treatment is beneficial in patients with IRSS stage III disease. IRSS stage IV retinoblastoma has poor prognosis despite treatment. [J Pediatr Ophthalmol Strabismus. 2017;54(3):177-184.]. Copyright 2017, SLACK Incorporated.
PURPOSE: To describe the clinical features and outcomes of patients with stage III or IV retinoblastoma. METHODS: This was a retrospective study of 80 patients. RESULTS: Based on the International Retinoblastoma Staging System (IRSS), the tumors (n = 81) belonged to stage IIIa (n = 38, 47%), IIIb (n = 1, 1%), IVa2 (n = 10, 12%), IVb1 (n = 14, 17%), and IVb3 (n = 18, 22%). Of 80 patients, 42 (53%) were compliant to treatment and 38 (47%) were non-compliant. All 38 patients who were non-compliant to treatment died of the disease at a mean duration of 13 months from diagnosis. Of the 42 patients compliant to treatment, 22 (52%) died before completion of treatment. Twenty patients with stage III disease (25%) could complete the multimodal treatment and 17 (71%) were alive and well at a median follow-up duration of 77 months. CONCLUSIONS: Compliant multimodality treatment is beneficial in patients with IRSS stage III disease. IRSS stage IV retinoblastoma has poor prognosis despite treatment. [J Pediatr Ophthalmol Strabismus. 2017;54(3):177-184.]. Copyright 2017, SLACK Incorporated.
Authors: Ido Didi Fabian; Elhassan Abdallah; Shehu U Abdullahi; Rula A Abdulqader; Sahadatou Adamou Boubacar; Dupe S Ademola-Popoola; Adedayo Adio; Armin R Afshar; Priyanka Aggarwal; Ada E Aghaji; Alia Ahmad; Marliyanti N R Akib; Lamis Al Harby; Mouroge H Al Ani; Aygun Alakbarova; Silvia Alarcón Portabella; Safaa A F Al-Badri; Ana Patricia A Alcasabas; Saad A Al-Dahmash; Amanda Alejos; Ernesto Alemany-Rubio; Amadou I Alfa Bio; Yvania Alfonso Carreras; Christiane Al-Haddad; Hamoud H Y Al-Hussaini; Amany M Ali; Donjeta B Alia; Mazin F Al-Jadiry; Usama Al-Jumaily; Hind M Alkatan; Charlotta All-Eriksson; Ali A R M Al-Mafrachi; Argentino A Almeida; Khalifa M Alsawidi; Athar A S M Al-Shaheen; Entissar H Al-Shammary; Primawita O Amiruddin; Romanzo Antonino; Nicholas J Astbury; Hatice T Atalay; La-Ongsri Atchaneeyasakul; Rose Atsiaya; Taweevat Attaseth; Than H Aung; Silvia Ayala; Baglan Baizakova; Julia Balaguer; Ruhengiz Balayeva; Walentyna Balwierz; Honorio Barranco; Covadonga Bascaran; Maja Beck Popovic; Raquel Benavides; Sarra Benmiloud; Nissrine Bennani Guebessi; Rokia C Berete; Jesse L Berry; Anirban Bhaduri; Sunil Bhat; Shelley J Biddulph; Eva M Biewald; Nadia Bobrova; Marianna Boehme; H C Boldt; Maria Teresa B C Bonanomi; Norbert Bornfeld; Gabrielle C Bouda; Hédi Bouguila; Amaria Boumedane; Rachel C Brennan; Bénédicte G Brichard; Jassada Buaboonnam; Patricia Calderón-Sotelo; Doris A Calle Jara; Jayne E Camuglia; Miriam R Cano; Michael Capra; Nathalie Cassoux; Guilherme Castela; Luis Castillo; Jaume Català-Mora; Guillermo L Chantada; Shabana Chaudhry; Sonal S Chaugule; Argudit Chauhan; Bhavna Chawla; Violeta S Chernodrinska; Faraja S Chiwanga; Tsengelmaa Chuluunbat; Krzysztof Cieslik; Ruellyn L Cockcroft; Codruta Comsa; Zelia M Correa; Maria G Correa Llano; Timothy W Corson; Kristin E Cowan-Lyn; Monika Csóka; Xuehao Cui; Isac V Da Gama; Wantanee Dangboon; Anirban Das; Sima Das; Jacquelyn M Davanzo; Alan Davidson; Patrick De Potter; Karina Q Delgado; Hakan Demirci; Laurence Desjardins; Rosdali Y Diaz Coronado; Helen Dimaras; Andrew J Dodgshun; Craig Donaldson; Carla R Donato Macedo; Monica D Dragomir; Yi Du; Magritha Du Bruyn; Kemala S Edison; I Wayan Eka Sutyawan; Asmaa El Kettani; Amal M Elbahi; James E Elder; Dina Elgalaly; Alaa M Elhaddad; Moawia M Ali Elhassan; Mahmoud M Elzembely; Vera A Essuman; Ted Grimbert A Evina; Zehra Fadoo; Adriana C Fandiño; Mohammad Faranoush; Oluyemi Fasina; Delia D P G Fernández; Ana Fernández-Teijeiro; Allen Foster; Shahar Frenkel; Ligia D Fu; Soad L Fuentes-Alabi; Brenda L Gallie; Moira Gandiwa; Juan L Garcia; David García Aldana; Pascale Y Gassant; Jennifer A Geel; Fariba Ghassemi; Ana V Girón; Zelalem Gizachew; Marco A Goenz; Aaron S Gold; Maya Goldberg-Lavid; Glen A Gole; Nir Gomel; Efren Gonzalez; Graciela Gonzalez Perez; Liudmira González-Rodríguez; Henry N Garcia Pacheco; Jaime Graells; Liz Green; Pernille A Gregersen; Nathalia D A K Grigorovski; Koffi M Guedenon; D Sanjeeva Gunasekera; Ahmet K Gündüz; Himika Gupta; Sanjiv Gupta; Theodora Hadjistilianou; Patrick Hamel; Syed A Hamid; Norhafizah Hamzah; Eric D Hansen; J William Harbour; M Elizabeth Hartnett; Murat Hasanreisoglu; Sadiq Hassan; Shadab Hassan; Stanislava Hederova; Jose Hernandez; Lorelay Marie Carcamo Hernandez; Laila Hessissen; Diriba F Hordofa; Laura C Huang; G B Hubbard; Marlies Hummlen; Kristina Husakova; Allawi N Hussein Al-Janabi; Russo Ida; Vesna R Ilic; Vivekaraj Jairaj; Irfan Jeeva; Helen Jenkinson; Xunda Ji; Dong Hyun Jo; Kenneth P Johnson; William J Johnson; Michael M Jones; Theophile B Amani Kabesha; Rolande L Kabore; Swathi Kaliki; Abubakar Kalinaki; Mehmet Kantar; Ling-Yuh Kao; Tamar Kardava; Rejin Kebudi; Tomas Kepak; Naama Keren-Froim; Zohora J Khan; Hussain A Khaqan; Phara Khauv; Wajiha J Kheir; Vikas Khetan; Alireza Khodabande; Zaza Khotenashvili; Jonathan W Kim; Jeong Hun Kim; Hayyam Kiratli; Tero T Kivelä; Artur Klett; Jess Elio Kosh Komba Palet; Dalia Krivaitiene; Mariana Kruger; Kittisak Kulvichit; Mayasari W Kuntorini; Alice Kyara; Eva S Lachmann; Carol P S Lam; Geoffrey C Lam; Scott A Larson; Slobodanka Latinovic; Kelly D Laurenti; Bao Han A Le; Karin Lecuona; Amy A Leverant; Cairui Li; Ben Limbu; Quah Boon Long; Juan P López; Robert M Lukamba; Livia Lumbroso; Sandra Luna-Fineman; Delfitri Lutfi; Lesia Lysytsia; George N Magrath; Amita Mahajan; Abdul Rahim Majeed; Erika Maka; Mayuri Makan; Emil K Makimbetov; Chatonda Manda; Nieves Martín Begue; Lauren Mason; John O Mason; Ibrahim O Matende; Miguel Materin; Clarissa C D S Mattosinho; Marchelo Matua; Ismail Mayet; Freddy B Mbumba; John D McKenzie; Aurora Medina-Sanson; Azim Mehrvar; Aemero A Mengesha; Vikas Menon; Gary John V D Mercado; Marilyn B Mets; Edoardo Midena; Divyansh K C Mishra; Furahini G Mndeme; Ahmed A Mohamedani; Mona T Mohammad; Annette C Moll; Margarita M Montero; Rosa A Morales; Claude Moreira; Prithvi Mruthyunjaya; Mchikirwa S Msina; Gerald Msukwa; Sangeeta S Mudaliar; Kangwa I Muma; Francis L Munier; Gabriela Murgoi; Timothy G Murray; Kareem O Musa; Asma Mushtaq; Hamzah Mustak; Okwen M Muyen; Gita Naidu; Akshay Gopinathan Nair; Larisa Naumenko; Paule Aïda Ndoye Roth; Yetty M Nency; Vladimir Neroev; Hang Ngo; Rosa M Nieves; Marina Nikitovic; Elizabeth D Nkanga; Henry Nkumbe; Murtuza Nuruddin; Mutale Nyaywa; Ghislaine Obono-Obiang; Ngozi C Oguego; Andrzej Olechowski; Scott C N Oliver; Peter Osei-Bonsu; Diego Ossandon; Manuel A Paez-Escamilla; Halimah Pagarra; Sally L Painter; Vivian Paintsil; Luisa Paiva; Bikramjit P Pal; Mahesh Shanmugam Palanivelu; Ruzanna Papyan; Raffaele Parrozzani; Manoj Parulekar; Claudia R Pascual Morales; Katherine E Paton; Katarzyna Pawinska-Wasikowska; Jacob Pe'er; Armando Peña; Sanja Peric; Chau T M Pham; Remezo Philbert; David A Plager; Pavel Pochop; Rodrigo A Polania; Vladimir G Polyakov; Manca T Pompe; Jonathan J Pons; Daphna Prat; Vireak Prom; Ignatius Purwanto; Ali O Qadir; Seema Qayyum; Jiang Qian; Ardizal Rahman; Salman Rahman; Jamalia Rahmat; Purnima Rajkarnikar; Rajesh Ramanjulu; Aparna Ramasubramanian; Marco A Ramirez-Ortiz; Léa Raobela; Riffat Rashid; M Ashwin Reddy; Ehud Reich; Lorna A Renner; David Reynders; Dahiru Ribadu; Mussagy M Riheia; Petra Ritter-Sovinz; Duangnate Rojanaporn; Livia Romero; Soma R Roy; Raya H Saab; Svetlana Saakyan; Ahmed H Sabhan; Mandeep S Sagoo; Azza M A Said; Rohit Saiju; Beatriz Salas; Sonsoles San Román Pacheco; Gissela L Sánchez; Phayvanh Sayalith; Trish A Scanlan; Amy C Schefler; Judy Schoeman; Ahad Sedaghat; Stefan Seregard; Rachna Seth; Ankoor S Shah; Shawkat A Shakoor; Manoj K Sharma; Sadik T Sherief; Nandan G Shetye; Carol L Shields; Sorath Noorani Siddiqui; Sidi Sidi Cheikh; Sónia Silva; Arun D Singh; Niharika Singh; Usha Singh; Penny Singha; Rita S Sitorus; Alison H Skalet; Hendrian D Soebagjo; Tetyana Sorochynska; Grace Ssali; Andrew W Stacey; Sandra E Staffieri; Erin D Stahl; Christina Stathopoulos; Branka Stirn Kranjc; David K Stones; Caron Strahlendorf; Maria Estela Coleoni Suarez; Sadia Sultana; Xiantao Sun; Meryl Sundy; Rosanne Superstein; Eddy Supriyadi; Supawan Surukrattanaskul; Shigenobu Suzuki; Karel Svojgr; Fatoumata Sylla; Gevorg Tamamyan; Deborah Tan; Alketa Tandili; Fanny F Tarrillo Leiva; Maryam Tashvighi; Bekim Tateshi; Edi S Tehuteru; Luiz F Teixeira; Kok Hoi Teh; Tuyisabe Theophile; Helen Toledano; Doan L Trang; Fousseyni Traoré; Sumalin Trichaiyaporn; Samuray Tuncer; Harba Tyau-Tyau; Ali B Umar; Emel Unal; Ogul E Uner; Steen F Urbak; Tatiana L Ushakova; Rustam H Usmanov; Sandra Valeina; Milo van Hoefen Wijsard; Adisai Varadisai; Liliana Vasquez; Leon O Vaughan; Nevyana V Veleva-Krasteva; Nishant Verma; Andi A Victor; Maris Viksnins; Edwin G Villacís Chafla; Vicktoria Vishnevskia-Dai; Tushar Vora; Antonio E Wachtel; Werner Wackernagel; Keith Waddell; Patricia D Wade; Amina H Wali; Yi-Zhuo Wang; Avery Weiss; Matthew W Wilson; Amelia D C Wime; Atchareeya Wiwatwongwana; Damrong Wiwatwongwana; Charlotte Wolley Dod; Phanthipha Wongwai; Daoman Xiang; Yishuang Xiao; Jason C Yam; Huasheng Yang; Jenny M Yanga; Muhammad A Yaqub; Vera A Yarovaya; Andrey A Yarovoy; Huijing Ye; Yacoub A Yousef; Putu Yuliawati; Arturo M Zapata López; Ekhtelbenina Zein; Chengyue Zhang; Yi Zhang; Junyang Zhao; Xiaoyu Zheng; Katsiaryna Zhilyaeva; Nida Zia; Othman A O Ziko; Marcia Zondervan; Richard Bowman Journal: JAMA Oncol Date: 2020-05-01 Impact factor: 31.777