| Literature DB >> 27975268 |
Asami Kondo1, Onder Albayram1, Xiao Zhen Zhou2, Kun Ping Lu3.
Abstract
Pin1 knockout in mice causes age-dependent neuropathy characterized by motor and behavioral deficits, tau hyper phosphorylation, tau filament formation, and neuronal degradation. Here, we describe the methods with mouse behavior test, immunostaining, and immunoblotting to detect many aspects of neurodegeneration in Pin1 knockout mice.Entities:
Keywords: Alzheimer’s disease; Behavior test; Cis P-tau; Immunoblotting; Immunohistochemistry; Pin1
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Year: 2017 PMID： 27975268 DOI： 10.1007/978-1-4939-6598-4_28
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745