Nazanin Saemi1,2, Jalaleddin Khoshnevis1, Mohammad Esmaeil Akbari1, Alipasha Meysamie3, Alireza Korourian4, Barmak Gholizadeh1, Leila Larijani1, Afshin Moradi1, Masoud Baikpour5, Maryam Baikpour2, Hanieh Zham6,7. 1. Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Medical Biotechnology Department, Iran University of Medical Sciences, Tehran, Iran. 3. Community Medicine Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran. 4. Cellular and Molecular Research Center, Faculty of Allied Sciences, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 6. Medical Biotechnology Department, Iran University of Medical Sciences, Tehran, Iran. h_zham@yahoo.com. 7. Cancer Research Center (CRC), Tajrish Shohada Hospital, Dr. Sharieati street, Ghods square, Tehran, Iran. h_zham@yahoo.com.
Abstract
OBJECTIVE: In the present study, we aimed to evaluate the relationship between the survival rate of patients with esophageal squamous cell carcinoma (SCC) and expression of two biomarkers along with age, gender, tumor margin, depth of invasion, site of tumor, tumor diameter, tumor grade, number of involved nodes, and vascular invasion. MATERIALS AND METHODS: In this retrospective survey, medical records of patients referred to the Shohada-e Tajrish hospital during 2001 to 2005 were reviewed and subjects with definite diagnosis of SCC were included. Required data were extracted from the patients' records, and their prepared paraffin-embedded tissue blocks were collected under supervision of two pathologists. Immunohistochemistry (IHC) analysis was performed at the Firoozgar hospital in Tehran, Iran. RESULTS: The studied population included 20 men (74%) and 7 women (26%). The mean age at diagnosis was 58 ± 22. Results showed significantly higher survival rates in women compared to men (85.7 vs. 40%) (p = 0.001) and in patients with well-differentiated tumors compared to poor-differentiated cases (20 vs. 5%) (p = 0.004). No significant relationship was found between p53 expression and prognostic factors like age, gender, the site, grade, and size of the tumor, depth of invasion, involvement of lymph nodes, and vascular invasion. CONCLUSION: Positivity of p53 and cyclin D1 was not found to be predictive of survival in patients with esophageal SCC which might be due to the small sample size of the present survey. Further investigations with larger sample populations and longer follow-ups are required to evaluate this correlation.
OBJECTIVE: In the present study, we aimed to evaluate the relationship between the survival rate of patients with esophageal squamous cell carcinoma (SCC) and expression of two biomarkers along with age, gender, tumor margin, depth of invasion, site of tumor, tumor diameter, tumor grade, number of involved nodes, and vascular invasion. MATERIALS AND METHODS: In this retrospective survey, medical records of patients referred to the Shohada-e Tajrish hospital during 2001 to 2005 were reviewed and subjects with definite diagnosis of SCC were included. Required data were extracted from the patients' records, and their prepared paraffin-embedded tissue blocks were collected under supervision of two pathologists. Immunohistochemistry (IHC) analysis was performed at the Firoozgar hospital in Tehran, Iran. RESULTS: The studied population included 20 men (74%) and 7 women (26%). The mean age at diagnosis was 58 ± 22. Results showed significantly higher survival rates in women compared to men (85.7 vs. 40%) (p = 0.001) and in patients with well-differentiated tumors compared to poor-differentiated cases (20 vs. 5%) (p = 0.004). No significant relationship was found between p53 expression and prognostic factors like age, gender, the site, grade, and size of the tumor, depth of invasion, involvement of lymph nodes, and vascular invasion. CONCLUSION: Positivity of p53 and cyclin D1 was not found to be predictive of survival in patients with esophageal SCC which might be due to the small sample size of the present survey. Further investigations with larger sample populations and longer follow-ups are required to evaluate this correlation.
Authors: S Chava; V Mohan; P J Shetty; M L Manolla; S Vaidya; I A Khan; G L Waseem; P Boddala; Y R Ahuja; Q Hasan Journal: Dis Esophagus Date: 2011-06-10 Impact factor: 3.429
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Authors: G Roshandel; S Merat; M Sotoudeh; M Khoshnia; H Poustchi; P Lao-Sirieix; S Malhotra; M O'Donovan; A Etemadi; A Nickmanesh; A Pourshams; A Norouzi; I Debiram; S Semnani; C C Abnet; S M Dawsey; R C Fitzgerald; R Malekzadeh Journal: Br J Cancer Date: 2014-09-23 Impact factor: 7.640