Katja Taxis1, Sjoerd Kochen1, Hans Wouters1, Froukje Boersma2, Maring Jan Gerard3, Hans Mulder4, Jugoslav Pavlovic1, Gerard Stevens5, Andrew McLachlan6, Lisa G Pont7. 1. Department of Pharmacy, Rijksuniversiteit Groningen Ringgold Standard Institution, Division of Pharmacotherapy and Pharmaceutical Care, Groningen, The Netherlands. 2. Department of General Practice, University Medical Center Groningen, Elderly Care Medicine, Groningen, The Netherlands. 3. Department of Pharmacy, Bethesda Ziekenhuis Ringgold Standard Institution, Hoogeveen, The Netherlands. 4. Department of Clinical Pharmacy, Wilhelmina Ziekenhuis Assen WZA Ringgold Standard Institution, Assen, Drenthe, The Netherlands. 5. Webstercare Ringgold Standard Institution, Five Dock, New South Wales, Australia. 6. University of Sydney, Faculty of Pharmacy, Sydney, New South Wales, Australia. 7. Macquarie University Ringgold Standard Institution, Australian Institute for Health Innovation, North Ryde, New South Wales 2109, Australia.
Abstract
Background: cross-national comparisons can be used to explore therapeutic areas and identify potential medication issues. Methods: we used cross-sectional pharmacy supply data to explore medication use for nursing home residents in Australia (AU n = 26 homes, 1,560 residents) and the Netherlands (NL n = 6 homes, 2,037 residents). Binary logistic regression analysis was used to calculate the sex and aged adjusted odds ratios (OR) and associated 95% confidence intervals with a flexible Bonferroni-Holm procedure used to adjust for multiple hypothesis testing. Results: total use of antipsychotics (AU: 37.7%, NL: 40.3%; OR 0.91 (0.79-1.04, P = 0.16) and antibacterials (66.8% AU, 62.4% NL, OR 1.08 (0.93-1.24, P = 0.31) was similar, but choice of individual agents differed between the two countries. Differences were observed in the use of antithrombotics (46.7% AU, 64.7% NL, OR 0.48 (0.42-0.56, P > 0.01), ophthalmologicals (44.3% AU, 22.1% NL, OR 2.80 (2.42-3.24, P < 0.001), laxatives (77.1% AU, 65.8% NL, OR 1.65 (1.41-1.92, P < 0.001). Conclusion: while the general prevalence of medication use in nursing home residents was similar across the two countries, distinct differences existed in the choice of agent among therapeutic groups. Comparing use between countries identified a number of potential medication related problem areas that need further exploration.
Background: cross-national comparisons can be used to explore therapeutic areas and identify potential medication issues. Methods: we used cross-sectional pharmacy supply data to explore medication use for nursing home residents in Australia (AU n = 26 homes, 1,560 residents) and the Netherlands (NL n = 6 homes, 2,037 residents). Binary logistic regression analysis was used to calculate the sex and aged adjusted odds ratios (OR) and associated 95% confidence intervals with a flexible Bonferroni-Holm procedure used to adjust for multiple hypothesis testing. Results: total use of antipsychotics (AU: 37.7%, NL: 40.3%; OR 0.91 (0.79-1.04, P = 0.16) and antibacterials (66.8% AU, 62.4% NL, OR 1.08 (0.93-1.24, P = 0.31) was similar, but choice of individual agents differed between the two countries. Differences were observed in the use of antithrombotics (46.7% AU, 64.7% NL, OR 0.48 (0.42-0.56, P > 0.01), ophthalmologicals (44.3% AU, 22.1% NL, OR 2.80 (2.42-3.24, P < 0.001), laxatives (77.1% AU, 65.8% NL, OR 1.65 (1.41-1.92, P < 0.001). Conclusion: while the general prevalence of medication use in nursing home residents was similar across the two countries, distinct differences existed in the choice of agent among therapeutic groups. Comparing use between countries identified a number of potential medication related problem areas that need further exploration.
Authors: L M J Sanders; T Hortobágyi; G van Staveren; K Taxis; F Boersma; H C Klein; W J R Bossers; C G Blankevoort; E J A Scherder; E A Van der Zee; M J G van Heuvelen Journal: Eur J Clin Pharmacol Date: 2017-09-18 Impact factor: 2.953
Authors: Helene G van der Meer; Katja Taxis; Martina Teichert; Fabiënne Griens; Lisa G Pont; Hans Wouters Journal: Pharmacoepidemiol Drug Saf Date: 2019-02-12 Impact factor: 2.890
Authors: Lynne Pezzullo; Jared Streatfeild; Josiah Hickson; Andrew Teodorczuk; Meera R Agar; Gideon A Caplan Journal: BMJ Open Date: 2019-09-17 Impact factor: 2.692
Authors: Francesca L La Frenais; Rachel Bedder; Victoria Vickerstaff; Patrick Stone; Elizabeth L Sampson Journal: J Am Geriatr Soc Date: 2017-12-23 Impact factor: 5.562