Literature DB >> 27974149

The threshold vs LNT showdown: Dose rate findings exposed flaws in the LNT model part 2. How a mistake led BEIR I to adopt LNT.

Edward J Calabrese1.   

Abstract

This paper reveals that nearly 25 years after the National Academy of Sciences (NAS), Biological Effects of Ionizing Radiation (BEIR) I Committee (1972) used Russell's dose-rate data to support the adoption of the linear-no-threshold (LNT) dose response model for genetic and cancer risk assessment, Russell acknowledged a significant under-reporting of the mutation rate of the historical control group. This error, which was unknown to BEIR I, had profound implications, leading it to incorrectly adopt the LNT model, which was a decision that profoundly changed the course of risk assessment for radiation and chemicals to the present.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Dose-rate; Hormesis; LNT; Linear dose response; Specific locus test

Mesh:

Year:  2016        PMID: 27974149     DOI: 10.1016/j.envres.2016.11.024

Source DB:  PubMed          Journal:  Environ Res        ISSN: 0013-9351            Impact factor:   6.498


  9 in total

Review 1.  Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.

Authors:  Ifigeneia V Mavragani; Zacharenia Nikitaki; Maria P Souli; Asef Aziz; Somaira Nowsheen; Khaled Aziz; Emmy Rogakou; Alexandros G Georgakilas
Journal:  Cancers (Basel)       Date:  2017-07-18       Impact factor: 6.639

Review 2.  Was Muller's 1946 Nobel Prize research for radiation-induced gene mutations peer-reviewed?

Authors:  Edward J Calabrese
Journal:  Philos Ethics Humanit Med       Date:  2018-06-06       Impact factor: 2.464

3.  The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT.

Authors:  Edward J Calabrese; Jaap C Hanekamp; Dima Yazji Shamoun
Journal:  Dose Response       Date:  2018-08-09       Impact factor: 2.658

Review 4.  Muller's nobel prize research and peer review.

Authors:  Edward J Calabrese
Journal:  Philos Ethics Humanit Med       Date:  2018-10-19       Impact factor: 2.464

5.  The Mistaken Birth and Adoption of LNT: An Abridged Version.

Authors:  Edward J Calabrese
Journal:  Dose Response       Date:  2017-10-09       Impact factor: 2.658

6.  It Is Time to Move Beyond the Linear No-Threshold Theory for Low-Dose Radiation Protection.

Authors:  John J Cardarelli; Brant A Ulsh
Journal:  Dose Response       Date:  2018-07-01       Impact factor: 2.658

7.  Radiophobia: 7 Reasons Why Radiography Used in Spine and Posture Rehabilitation Should Not Be Feared or Avoided.

Authors:  Paul A Oakley; Deed E Harrison
Journal:  Dose Response       Date:  2018-06-27       Impact factor: 2.658

Review 8.  Hormesis: Path and Progression to Significance.

Authors:  Edward J Calabrese
Journal:  Int J Mol Sci       Date:  2018-09-21       Impact factor: 5.923

9.  The Selby-Russell Dispute Regarding the Nonreporting of Critical Data in the Mega-Mouse Experiments of Drs William and Liane Russell That Spanned Many Decades: What Happened, Current Status, and Some Ramifications.

Authors:  P B Selby
Journal:  Dose Response       Date:  2020-02-12       Impact factor: 2.658

  9 in total

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