Literature DB >> 2797178

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.

Y Nakano1, I Guerrero, A Hidalgo, A Taylor, J R Whittle, P W Ingham.   

Abstract

The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

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Year:  1989        PMID: 2797178     DOI: 10.1038/341508a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  66 in total

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Review 5.  Proteostasis in the Hedgehog signaling pathway.

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6.  Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

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Review 9.  Medulloblastoma: molecular genetics and animal models.

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10.  The role of hedgehog-interacting protein in maintaining cavernous nerve integrity and adult penile morphology.

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