Literature DB >> 27967205

Gestational Hyperandrogenism in Developmental Programming.

Christopher Hakim1, Vasantha Padmanabhan2, Arpita K Vyas1,3.   

Abstract

Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.
Copyright © 2017 by the Endocrine Society.

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Year:  2017        PMID： 27967205      PMCID： PMC5413081          DOI： 10.1210/en.2016-1801

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  179 in total

Review 1.  Steroidogenic versus Metabolic Programming of Reproductive Neuroendocrine, Ovarian and Metabolic Dysfunctions.

Authors:  Rodolfo C Cardoso; Muraly Puttabyatappa; Vasantha Padmanabhan
Journal:  Neuroendocrinology       Date:  2015-04-01       Impact factor: 4.914

Review 2.  Androgen production in women.

Authors:  Henry G Burger
Journal:  Fertil Steril       Date:  2002-04       Impact factor: 7.329

Review 3.  Androgen biology as a basis for the diagnosis and treatment of androgenic disorders in women. II.

Authors:  L C Sperling; W L Heimer
Journal:  J Am Acad Dermatol       Date:  1993-06       Impact factor: 11.527

4.  Pre-eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study from the Walker cohort.

Authors:  G Libby; D J Murphy; N F McEwan; S A Greene; J S Forsyth; P W Chien; A D Morris
Journal:  Diabetologia       Date:  2006-12-23       Impact factor: 10.122

5.  Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction.

Authors:  Toru Takeuchi; Osamu Tsutsumi; Yumiko Ikezuki; Yasushi Takai; Yuji Taketani
Journal:  Endocr J       Date:  2004-04       Impact factor: 2.349

6.  Testosterone alters maternal vascular adaptations: role of the endothelial NO system.

Authors:  Vijayakumar Chinnathambi; Meena Balakrishnan; Jayanth Ramadoss; Chandrasekhar Yallampalli; Kunju Sathishkumar
Journal:  Hypertension       Date:  2013-01-21       Impact factor: 10.190

Review 7.  Sexual differentiation of reproductive neuroendocrine function in sheep.

Authors:  R I Wood; D L Foster
Journal:  Rev Reprod       Date:  1998-05

Review 8.  Undernutrition and growth restriction in pregnancy.

Authors:  Renate L Bergmann; Karl E Bergmann; J W Dudenhausen
Journal:  Nestle Nutr Workshop Ser Pediatr Program       Date:  2008

9.  In utero exposure to the environmental androgen trenbolone masculinizes female Sprague-Dawley rats.

Authors:  A K Hotchkiss; J Furr; E A Makynen; G T Ankley; L E Gray
Journal:  Toxicol Lett       Date:  2007-08-25       Impact factor: 4.372

Review 10.  Autism spectrum disorders--a genetics review.

Authors:  Judith H Miles
Journal:  Genet Med       Date:  2011-04       Impact factor: 8.822
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  27 in total

1.  Neuronal androgen receptor: Molecular gateway to polycystic ovary syndrome?

Authors:  David H Abbott
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-04       Impact factor: 11.205

2.  Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens.

Authors:  Grace Huang; Sara Cherkerzian; Eric B Loucks; Stephen L Buka; Robert J Handa; Bill L Lasley; Shalender Bhasin; Jill M Goldstein
Journal:  J Clin Endocrinol Metab       Date:  2018-11-01       Impact factor: 5.958

Review 3.  A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome.

Authors:  Angela S Kelley; Yolanda R Smith; Vasantha Padmanabhan
Journal:  J Clin Endocrinol Metab       Date:  2019-11-01       Impact factor: 5.958

4.  Developmental programming: Sex-specific programming of growth upon prenatal bisphenol A exposure.

Authors:  Arpita Kalla Vyas; Almudena Veiga-Lopez; Wen Ye; Bachir Abi Salloum; David H Abbott; Shengping Yang; Chunyang Liao; Kurunthachalam Kannan; Vasantha Padmanabhan
Journal:  J Appl Toxicol       Date:  2019-07-23       Impact factor: 3.446

5.  Prenatal Testosterone Excess Disrupts Placental Function in a Sheep Model of Polycystic Ovary Syndrome.

Authors:  Angela S Kelley; Muraly Puttabyatappa; Joseph N Ciarelli; Lixia Zeng; Yolanda R Smith; Richard Lieberman; Subramaniam Pennathur; Vasantha Padmanabhan
Journal:  Endocrinology       Date:  2019-11-01       Impact factor: 4.736

Review 6.  Developmental Programming of Ovarian Functions and Dysfunctions.

Authors:  Muraly Puttabyatappa; Vasantha Padmanabhan
Journal:  Vitam Horm       Date:  2018-02-22       Impact factor: 3.421

Review 7.  Vascular Pathways of Testosterone: Clinical Implications.

Authors:  Margarida Lorigo; Melissa Mariana; Nelson Oliveira; Manuel C Lemos; Elisa Cairrao
Journal:  J Cardiovasc Transl Res       Date:  2019-12-09       Impact factor: 4.132

8.  Developmental programming: Metabolic tissue-specific changes in endoplasmic reticulum stress, mitochondrial oxidative and telomere length status induced by prenatal testosterone excess in the female sheep.

Authors:  Muraly Puttabyatappa; Joseph N Ciarelli; Adam G Chatoff; Vasantha Padmanabhan
Journal:  Mol Cell Endocrinol       Date:  2021-02-17       Impact factor: 4.102

9.  Maternal hyperandrogenism is associated with a higher risk of type 2 diabetes mellitus and overweight in adolescent and adult female offspring: a long-term population-based follow-up study.

Authors:  M Noroozzadeh; M Rahmati; S Behboudi-Gandevani; F Ramezani Tehrani
Journal:  J Endocrinol Invest       Date:  2022-01-19       Impact factor: 4.256

10.  RAPIDLY PROGRESSIVE AND SEVERE HIRSUTISM FROM HYPERREACTIO LUTEINALIS WITHIN A BACKGROUND OF POLYCYSTIC OVARY SYNDROME.

Authors:  Hannah Miriam Mathew; Christopher Wang Lee; Shirin Haddady
Journal:  AACE Clin Case Rep       Date:  2018-11-01
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