Studies on the suppression of HL-60 cell growth in vitro by low molecular weight suppressor of human fetal liver origin.

In human fetal liver there are at least two kinds of cell growth suppressor, arginase and a low molecular weight suppressor, both are cytotoxic towards HL-60 cells under the condition of in vitro culture, and mainly present in the supernatant of fetal liver cell suspension. As compared with arginase, the low molecular weight suppressor shows a preferential suppression on HL-60 cell growth rather than that of granuloid-macrophage progenitors of normal human bone marrow.