Shariq Najeeb1, Fahad Siddiqui2, Zohaib Khurshid3, Sana Zohaib4, Muhammad Sohail Zafar5, Shazia Akbar Ansari6. 1. Department of Dentistry, Riyadh Consultative Clinics, Riyadh, Saudi Arabia. 2. Department of Pediatric Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey, USA. 3. Department of Prosthodontics and Implantology, King Faisal University, Al-Hofuf, Saudi Arabia. 4. School of Biomedical Engineering, King Faisal University, Al-Hofuf, Saudi Arabia. 5. Department of Restorative Dentistry, Taibah University, Madinah Al Munawwarah, Saudi Arabia. 6. Department of Oral Microbiology, Dow University of Health Sciences, Karachi, Pakistan.
Abstract
BACKGROUND/AIM: Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth. MATERIALS AND METHODS: PubMed/MEDLINE, Google Scholar, ISI Web of Knowledge, and Embase databases were searched using keywords 'bisphosphonate', 'replantation', and 'tooth'. Quality assessment of each study was carried out. In addition, general characteristics and outcomes of each study were summarized. RESULTS: After exclusion of 116 irrelevant articles, 10 animal studies were included in this review. The majority of the studies suggest that surface application of zoledronate or alendronate reduces root resorption of replanted teeth in animal models. Surface treatment with etidronate had no significant effect on root resorption, and intracanal etidronate accelerated resorption. CONCLUSION: Surface application of zoledronate and alendronate reduces root resorption of replanted teeth in animal models. However, the efficacy of intracanal usage of BPs is still debatable.
BACKGROUND/AIM: Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an antiresorptive effect on periodontal bone as well. The antiresorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarize the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth. MATERIALS AND METHODS: PubMed/MEDLINE, Google Scholar, ISI Web of Knowledge, and Embase databases were searched using keywords 'bisphosphonate', 'replantation', and 'tooth'. Quality assessment of each study was carried out. In addition, general characteristics and outcomes of each study were summarized. RESULTS: After exclusion of 116 irrelevant articles, 10 animal studies were included in this review. The majority of the studies suggest that surface application of zoledronate or alendronate reduces root resorption of replanted teeth in animal models. Surface treatment with etidronate had no significant effect on root resorption, and intracanal etidronate accelerated resorption. CONCLUSION: Surface application of zoledronate and alendronate reduces root resorption of replanted teeth in animal models. However, the efficacy of intracanal usage of BPs is still debatable.
Authors: Reham N AlJasser; Mohammed A AlSarhan; Dalal H Alotaibi; Saleh AlOraini; Abdul Sadekh Ansari; Syed Rashid Habib; Muhammad Sohail Zafar Journal: J Multidiscip Healthc Date: 2021-05-25
Authors: Emily Y Chu; Janina Golob Deeb; Brian L Foster; Evlambia Hajishengallis; Martha J Somerman; Vivek Thumbigere-Math Journal: Front Dent Med Date: 2021-03-26