Literature DB >> 27956418

Chromosome-Encoded Broad-Spectrum Ambler Class A β-Lactamase RUB-1 from Serratia rubidaea.

Rémy A Bonnin1,2,3, Jennifer Didi1, Ayla Ergani1, Sandra Lima1, Thierry Naas4,2,3,5.   

Abstract

Whole-genome sequencing of Serratia rubidaea CIP 103234T revealed a chromosomally located Ambler class A β-lactamase gene. The gene was cloned, and the β-lactamase, RUB-1, was characterized. RUB-1 displayed 74% and 73% amino acid sequence identity with the GIL-1 and TEM-1 penicillinases, respectively, and its substrate profile was similar to that of the latter β-lactamases. Analysis by 5' rapid amplification of cDNA ends revealed promoter sequences highly divergent from the Escherichia coli σ70 consensus sequence. This work further illustrates the heterogeneity of β-lactamases among Serratia spp.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  RUB-1; Serratia rubidaea; class A; β-lactamase

Mesh：

Substances：

Year:  2017        PMID： 27956418      PMCID： PMC5278729          DOI： 10.1128/AAC.01908-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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Review 3.  Updated functional classification of beta-lactamases.

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6.  Taxonomy of the genus Serratia.

Authors:  P A Grimont; F Grimont; H L De Rosnay
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Authors:  T Naas; L Vandel; W Sougakoff; D M Livermore; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191

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9.  Natural antimicrobial susceptibilities of strains of 'unusual' Serratia species: S. ficaria, S. fonticola, S. odorifera, S. plymuthica and S. rubidaea.

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10.  Draft Genome Sequence of the Serratia rubidaea CIP 103234T Reference Strain, a Human-Opportunistic Pathogen.

Authors:  Rémy A Bonnin; Delphine Girlich; Dilek Imanci; Laurent Dortet; Thierry Naas
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