Elaine Lai-Han Leung1, Emilio Clementi2, W S Fred Wong3. 1. State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address: lhleung@must.edu.mo. 2. Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital 'Luigi Sacco', Milan, Italy. 3. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.