Humberto Parada1, Susan E Steck2, Rebecca J Cleveland3, Susan L Teitelbaum4, Alfred I Neugut5, Regina M Santella6, Marilie D Gammon7. 1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill. Electronic address: hparada@live.unc.edu. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia. 3. Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill. 4. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. 5. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. 6. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY. 7. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Abstract
PURPOSE: To examine associations between 22 CYP single nucleotide polymorphisms (SNPs) and breast cancer incidence and their interactions with grilled-smoked meat intake, a source of polycyclic aromatic hydrocarbons. METHODS: White women with first primary in situ or invasive breast cancer (n = 988) and frequency-matched controls (n = 1021) from a population-based study were interviewed to assess lifetime grilled-smoked meat intake. SNPs with minor allele frequencies of greater than 0.05 were selected because of their links to carcinogenesis. We used multivariable unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Breast cancer was inversely associated with CYP1A1 rs104C8943 AG + GG genotype (OR = 0.71, 95% CI = 0.50-0.99; vs. AA genotype) and positively associated with CYP1B1 rs10175338 TT genotype (OR = 1.59, 95% CI = 1.12-2.26; vs. GG genotype) and the CYP3A4 rs2242480 CT + TT genotype (OR = 1.25, 95% CI = 1.00-1.56; vs. CC genotype). The sum of the number of "at-risk" alleles for the CYP SNPs was positively associated with breast cancer incidence (4-6 "at-risk" alleles OR = 2.33, 95% CI = 1.37-3.99 vs. 0-1 alleles; PTrend < .01). We observed multiplicative and additive interactions (P < .05) between grilled-smoked meat intake (low vs. high) with CYP1A1 rs1048943 and CYP1B1 rs10175338 SNPs. CONCLUSIONS: Phase I metabolizing enzyme gene SNPs may play a role in breast cancer development and may modify the grilled-smoked meat intake-breast cancer association.
PURPOSE: To examine associations between 22 CYP single nucleotide polymorphisms (SNPs) and breast cancer incidence and their interactions with grilled-smoked meat intake, a source of polycyclic aromatic hydrocarbons. METHODS: White women with first primary in situ or invasive breast cancer (n = 988) and frequency-matched controls (n = 1021) from a population-based study were interviewed to assess lifetime grilled-smoked meat intake. SNPs with minor allele frequencies of greater than 0.05 were selected because of their links to carcinogenesis. We used multivariable unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS:Breast cancer was inversely associated with CYP1A1 rs104C8943 AG + GG genotype (OR = 0.71, 95% CI = 0.50-0.99; vs. AA genotype) and positively associated with CYP1B1rs10175338 TT genotype (OR = 1.59, 95% CI = 1.12-2.26; vs. GG genotype) and the CYP3A4rs2242480CT + TT genotype (OR = 1.25, 95% CI = 1.00-1.56; vs. CC genotype). The sum of the number of "at-risk" alleles for the CYP SNPs was positively associated with breast cancer incidence (4-6 "at-risk" alleles OR = 2.33, 95% CI = 1.37-3.99 vs. 0-1 alleles; PTrend < .01). We observed multiplicative and additive interactions (P < .05) between grilled-smoked meat intake (low vs. high) with CYP1A1rs1048943 and CYP1B1rs10175338 SNPs. CONCLUSIONS: Phase I metabolizing enzyme gene SNPs may play a role in breast cancer development and may modify the grilled-smoked meat intake-breast cancer association.
Authors: Andrew D Johnson; Robert E Handsaker; Sara L Pulit; Marcia M Nizzari; Christopher J O'Donnell; Paul I W de Bakker Journal: Bioinformatics Date: 2008-10-30 Impact factor: 6.937
Authors: Marilie D Gammon; Regina M Santella; Alfred I Neugut; Sybil M Eng; Susan L Teitelbaum; Andrea Paykin; Bruce Levin; Mary Beth Terry; Tie Lan Young; Lian Wen Wang; Qiao Wang; Julie A Britton; Mary S Wolff; Steven D Stellman; Maureen Hatch; Geoffrey C Kabat; Ruby Senie; Gail Garbowski; Carla Maffeo; Pat Montalvan; Gertrud Berkowitz; Margaret Kemeny; Marc Citron; Freya Schnabel; Allan Schuss; Steven Hajdu; Vincent Vinceguerra Journal: Cancer Epidemiol Biomarkers Prev Date: 2002-08 Impact factor: 4.254
Authors: W Zheng; D R Gustafson; R Sinha; J R Cerhan; D Moore; C P Hong; K E Anderson; L H Kushi; T A Sellers; A R Folsom Journal: J Natl Cancer Inst Date: 1998-11-18 Impact factor: 13.506
Authors: C B Ambrosone; J L Freudenheim; S Graham; J R Marshall; J E Vena; J R Brasure; R Laughlin; T Nemoto; A M Michalek; A Harrington Journal: Cancer Res Date: 1995-08-15 Impact factor: 12.701