Literature DB >> 27955901

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal.

Jason E Hawkes1, Johann E Gudjonsson2, Nicole L Ward3.   

Abstract

Since 2009, the imiquimod- or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of acute skin inflammation has become the most widely used mouse model in preclinical psoriasis studies. Although this model offers researchers numerous benefits, there are important limitations and possible confounding variables to consider. The imiquimod model requires careful consideration and warrants scrutiny of the data generated by its use. In this perspective, we provide an overview of the advantages and disadvantages of this mouse model and offer suggestions for its use in psoriasis research.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27955901      PMCID： PMC5326590          DOI： 10.1016/j.jid.2016.10.024

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  28 in total

1.  Aldara®-induced skin inflammation: studies of patients with psoriasis.

Authors:  H Vinter; L Iversen; T Steiniche; K Kragballe; C Johansen
Journal:  Br J Dermatol       Date:  2014-12-10       Impact factor: 9.302

2.  Effects of Depilation Methods on Imiquimod-Induced Skin Inflammation in Mice.

Authors:  Nicole Amberg; Martin Holcmann; Gabriel Stulnig; Elisabeth Glitzner; Maria Sibilia
Journal:  J Invest Dermatol       Date:  2016-09-30       Impact factor: 8.551

3.  Imiquimod-induced subacute cutaneous lupus erythematosus-like changes.

Authors:  Sheilagh M Maguiness; Terry T Farsani; Daniel C Zedek; Timothy G Berger
Journal:  Cutis       Date:  2015-06

4.  Innate immune response in Th1- and Th2-dominant mouse strains.

Authors:  Hiroyuki Watanabe; Kousuke Numata; Takaaki Ito; Katsumasa Takagi; Akihiro Matsukawa
Journal:  Shock       Date:  2004-11       Impact factor: 3.454

5.  IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.

Authors:  Hye-Lin Ha; Hongshan Wang; Prapaporn Pisitkun; Jin-Chul Kim; Ilaria Tassi; Wanhu Tang; Maria I Morasso; Mark C Udey; Ulrich Siebenlist
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-04       Impact factor: 11.205

6.  Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice.

Authors:  H Vinter; K Kragballe; T Steiniche; M Gaestel; L Iversen; C Johansen
Journal:  Br J Dermatol       Date:  2016-02-08       Impact factor: 9.302

7.  Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus.

Authors:  Maki Yokogawa; Mikiro Takaishi; Kimiko Nakajima; Reiko Kamijima; Chisa Fujimoto; Sayo Kataoka; Yoshio Terada; Shigetoshi Sano
Journal:  Arthritis Rheumatol       Date:  2014-03       Impact factor: 10.995

8.  Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.

Authors:  William R Swindell; Andrew Johnston; Steve Carbajal; Gangwen Han; Christian Wohn; Jun Lu; Xianying Xing; Rajan P Nair; John J Voorhees; James T Elder; Xiao-Jing Wang; Shigetoshi Sano; Errol P Prens; John DiGiovanni; Mark R Pittelkow; Nicole L Ward; Johann E Gudjonsson
Journal:  PLoS One       Date:  2011-04-04       Impact factor: 3.240

9.  T cell genetic background determines default T helper phenotype development in vitro.

Authors:  C S Hsieh; S E Macatonia; A O'Garra; K M Murphy
Journal:  J Exp Med       Date:  1995-02-01       Impact factor: 14.307

10.  Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models.

Authors:  Jackelyn B Golden; Yunmei Wang; Yi Fritz; Doina Diaconu; Xiufen Zhang; Sara M Debanne; Daniel I Simon; Thomas S McCormick; Nicole L Ward
Journal:  J Transl Med       Date:  2015-12-16       Impact factor: 5.531
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  23 in total

Review 1.  Research Techniques Made Simple: Murine Models of Human Psoriasis.

Authors:  Jason E Hawkes; Jonas A Adalsteinsson; Johann E Gudjonsson; Nicole L Ward
Journal:  J Invest Dermatol       Date:  2018-01       Impact factor: 8.551

2.  Loss of Methylation Modification Marks the Presence of Psoriasis.

Authors:  Brian C Capell; John T Seykora
Journal:  J Invest Dermatol       Date:  2020-06       Impact factor: 8.551

3.  Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

Authors:  Robert J Cherney; Lyndon A M Cornelius; Anurag Srivastava; Carolyn A Weigelt; David Marcoux; James J-W Duan; Qing Shi; Douglas G Batt; Qingjie Liu; Shiuhang Yip; Dauh-Rurng Wu; Max Ruzanov; John Sack; Javed Khan; Jinhong Wang; Melissa Yarde; Mary Ellen Cvijic; Arvind Mathur; Sha Li; David Shuster; Purnima Khandelwal; Virna Borowski; Jenny Xie; Mary Obermeier; Aberra Fura; Kevin Stefanski; Georgia Cornelius; Joseph A Tino; John E Macor; Luisa Salter-Cid; Rex Denton; Qihong Zhao; Percy H Carter; T G Murali Dhar
Journal:  ACS Med Chem Lett       Date:  2020-03-31       Impact factor: 4.345

4.  Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis.

Authors:  Marta Consuegra-Fernández; Marc Julià; Mario Martínez-Florensa; Fernando Aranda; Cristina Català; Noelia Armiger-Borràs; María-Teresa Arias; Francisca Santiago; Antonio Guilabert; Anna Esteve; Carlos Muñoz; Carlos Ferrándiz; José-Manuel Carrascosa; Edurne Pedrosa; Jorge Romaní; Mercè Alsina; José-Manuel Mascaró-Galy; Francisco Lozano
Journal:  Cell Mol Immunol       Date:  2017-12-11       Impact factor: 11.530

5.  The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice.

Authors:  Nicholas J Geraghty; Kylie J Mansfield; Stephen J Fuller; Debbie Watson; Ronald Sluyter
Journal:  Purinergic Signal       Date:  2017-06-08       Impact factor: 3.765

6.  A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis.

Authors:  Yihua Cai; Feng Xue; Chen Quan; Minye Qu; Na Liu; Yuan Zhang; Chris Fleming; Xiaoling Hu; Huang-Ge Zhang; Ralph Weichselbaum; Yang-Xin Fu; David Tieri; Eric C Rouchka; Jie Zheng; Jun Yan
Journal:  J Invest Dermatol       Date:  2018-08-16       Impact factor: 8.551

7.  Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.

Authors:  Feng Li; Christine W Yuan; Shuyun Xu; Tingjian Zu; Yvon Woappi; Catherine A A Lee; Phammela Abarzua; Michael Wells; Matthew R Ramsey; Natasha Y Frank; Xunwei Wu; Anna Mandinova; Markus H Frank; Christine G Lian; George F Murphy
Journal:  J Invest Dermatol       Date:  2019-12-11       Impact factor: 8.551

Review 8.  Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis.

Authors:  Jason E Hawkes; Bernice Y Yan; Tom C Chan; James G Krueger
Journal:  J Immunol       Date:  2018-09-15       Impact factor: 5.422

9.  Transient Induction of Fever in the Imiquimod C57BL/6 Mouse Model of Psoriasis-Like Disease Involves IL-1 and IL-6 but Not IL-36.

Authors:  Shuang Sun; Laurie E Kilpatrick; Liselotte E Jensen
Journal:  J Invest Dermatol       Date:  2021-07-17       Impact factor: 8.551

Review 10.  "Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.

Authors:  Ranjitha Uppala; Lam C Tsoi; Paul W Harms; Bo Wang; Allison C Billi; Emanual Maverakis; J Michelle Kahlenberg; Nicole L Ward; Johann E Gudjonsson
Journal:  Cell Mol Immunol       Date:  2020-08-19       Impact factor: 11.530
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