Tadashi Tomo1. 1. Clinical Engineering Research Center, Faculty of Medicine, Oita University, Yufu City, Japan.
Abstract
BACKGROUND: Biocompatibility and the efficiency of solute removal are important considerations in blood purification therapy. Improvement of biocompatibility is expected to lead to the prevention of dialysis-related complications (e.g. amyloidosis, arteriosclerosis, and malnutrition) and to the delay of disease progression by alleviating microinflammation. SUMMARY: The biocompatibility of dialyzers is greatly influenced by the interaction between blood and the treatment materials, in which the chemical and physical characteristics of membrane materials play important roles. In hemodiafiltration (HDF), treatment characteristics such as dilution modes are also considered to greatly affect this interaction between blood and materials. Studies have reported that the levels of C-reactive protein are decreased in patients receiving HDF. Thus, the improvement of biocompatibility is an important factor in HDF. Key Messages: To improve the biocompatibility of HDF, it is essential to improve the biocompatibility of hemodiafilters. This article outlines the importance of biocompatibility and related factors in HDF.
BACKGROUND: Biocompatibility and the efficiency of solute removal are important considerations in blood purification therapy. Improvement of biocompatibility is expected to lead to the prevention of dialysis-related complications (e.g. amyloidosis, arteriosclerosis, and malnutrition) and to the delay of disease progression by alleviating microinflammation. SUMMARY: The biocompatibility of dialyzers is greatly influenced by the interaction between blood and the treatment materials, in which the chemical and physical characteristics of membrane materials play important roles. In hemodiafiltration (HDF), treatment characteristics such as dilution modes are also considered to greatly affect this interaction between blood and materials. Studies have reported that the levels of C-reactive protein are decreased in patients receiving HDF. Thus, the improvement of biocompatibility is an important factor in HDF. Key Messages: To improve the biocompatibility of HDF, it is essential to improve the biocompatibility of hemodiafilters. This article outlines the importance of biocompatibility and related factors in HDF.
Authors: Francesco Galli; Mario Bonomini; Desirée Bartolini; Linda Zatini; Gianpaolo Reboldi; Giada Marcantonini; Giorgio Gentile; Vittorio Sirolli; Natalia Di Pietro Journal: Antioxidants (Basel) Date: 2022-05-18
Authors: Maria Gabriela Picelli de Azevedo; Silvano Salgueiro Geraldes; Paula Bilbau Sant'Anna; Beatriz Poloni Batista; Suellen Rodrigues Maia; Reiner Silveira de Moraes; Elizabeth Moreira Dos Santos Schmidt; Fabiana Ferreira de Souza; Alessandra Melchert; João Carlos Pinheiro Ferreira; Carmel Rezende Dadalto; Henry David Mogollón García; Priscylla Tatiana Chalfun Guimarães-Okamoto Journal: PLoS One Date: 2022-09-22 Impact factor: 3.752