Literature DB >> 27942826

Autonomic function and control of pancreatic somatostatin.

E Samols1,2, J I Stagner1,2, G C Weir1,2.   

Abstract

In the canine pancreas alpha and beta adrenergic receptors exist on D cells with α stimulation inhibiting and β stimulation increasing somatostatin release. There are no dopaminergic receptors on D cells. Stimulation of muscarinic receptors causes mild inhibition of somatostatin secretion. Autonomic receptors on the D cell may be physiologically stimulated in vivo via local ganglionic and/or central autonomic drivers.

Entities:  

Keywords:  Somatostatin; acetylcholine; adrenergic receptors; autonomic; cholinergic receptors; dopamine; glucagon; insulin; pancreas

Year:  1981        PMID： 27942826     DOI： 10.1007/BF00254507

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  8 in total

1.  Characteristics of the dopaminergic and noradrenergic systems of the pancreatic islets.

Authors:  R T Zern; L B Foster; J A Blalock; J M Feldman
Journal:  Diabetes       Date:  1979-03       Impact factor: 9.461

2.  Modulation of pancreatic somatostatin by adrenergic and cholinergic agonism and by hyper- and hypoglycemic sulfonamides.

Authors:  E Samols; G C Weir; R Ramseur; J A Day; Y C Patel
Journal:  Metabolism       Date:  1978-09       Impact factor: 8.694

3.  Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects.

Authors:  M Lorenzi; J H Karam; E Tsalikian; N V Bohannon; J E Gerich; P H Forsham
Journal:  J Clin Invest       Date:  1979-02       Impact factor: 14.808

4.  Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas.

Authors:  E Samols; G C Weir
Journal:  J Clin Invest       Date:  1979-02       Impact factor: 14.808

5.  Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration.

Authors:  J I Stagner; E Samols; G C Weir
Journal:  J Clin Invest       Date:  1980-04       Impact factor: 14.808

6.  Characterisation of somatostatin release from the pancreas: the role of calcium and acetylcholine.

Authors:  K Hermansen; S E Christensen; H Orskov
Journal:  Diabetologia       Date:  1979-04       Impact factor: 10.122

7.  Haloperidol, a dopaminergic antagonist: somatostatin-like inhibition of glucagon and insulin release from the isolated, perfused canine pancreas.

Authors:  K Hermansen
Journal:  Diabetologia       Date:  1978-10       Impact factor: 10.122

8.  Reinterpretation of the effect of haloperidol and ethanol on insulin secretion.

Authors:  E Samols; J I Stagner
Journal:  Diabetologia       Date:  1980-07       Impact factor: 10.122
  8 in total
  3 in total

1.  Effects of physiological increases in plasma noradrenaline on the human endocrine pancreas.

Authors:  J Järhult; L O Farnebo; H Graffner; J Holst
Journal:  J Endocrinol Invest       Date:  1989-06       Impact factor: 4.256

Review 2.  Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion.

Authors:  B Ahrén; G J Taborsky; D Porte
Journal:  Diabetologia       Date:  1986-12       Impact factor: 10.122

3.  A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.

Authors:  Hong-Mei Wang; Jun-Hong Dong; Qing Li; Qiaoxia Hu; Shang-Lei Ning; Wenshuai Zheng; Min Cui; Tian-Sheng Chen; Xin Xie; Jin-Peng Sun; Xiao Yu
Journal:  Diabetologia       Date:  2014-06-20       Impact factor: 10.122
  3 in total

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