Karn Wijarnpreecha1, Charat Thongprayoon1, Panadeekarn Panjawatanan2, Patompong Ungprasert3. 1. Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA. 2. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. 3. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA; ; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Abstract
BACKGROUND: Hepatitis B virus (HBV)-infected patients might be associated with coronary artery disease (CAD) from process of chronic inflammation. However, available studies yield conflicting results. This meta-analysis was performed to assess risk of CAD in HBV-infected patients. METHODS: We searched MEDLINE and EMBASE for relevant literatures from database inception to June 2016. Studies comparing the risk of CAD among HBV-infected patients versus subjects without HBV infection using hazard ratio (HR), odd ratios, or relative risk (RR) were included. Random-effect model and generic inverse variance method were used to combine odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of five studies, including three cross-sectional studies, one case-control study, and one cohort study, were subjected to analysis. The result demonstrates no significant risk of CAD among chronic HBV-infected patients and subjects without HBV infection (OR, 0.68; 95% CI, 0.40-1.13). CONCLUSIONS: This meta-analysis did not demonstrate a significantly increased risk of CAD among HBV-infected patients.
BACKGROUND:Hepatitis B virus (HBV)-infectedpatients might be associated with coronary artery disease (CAD) from process of chronic inflammation. However, available studies yield conflicting results. This meta-analysis was performed to assess risk of CAD in HBV-infectedpatients. METHODS: We searched MEDLINE and EMBASE for relevant literatures from database inception to June 2016. Studies comparing the risk of CAD among HBV-infectedpatients versus subjects without HBV infection using hazard ratio (HR), odd ratios, or relative risk (RR) were included. Random-effect model and generic inverse variance method were used to combine odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of five studies, including three cross-sectional studies, one case-control study, and one cohort study, were subjected to analysis. The result demonstrates no significant risk of CAD among chronic HBV-infectedpatients and subjects without HBV infection (OR, 0.68; 95% CI, 0.40-1.13). CONCLUSIONS: This meta-analysis did not demonstrate a significantly increased risk of CAD among HBV-infectedpatients.
Authors: Shanthi Mendis; Dele Abegunde; Salim Yusuf; Shah Ebrahim; Gerry Shaper; Hassen Ghannem; Bakuti Shengelia Journal: Bull World Health Organ Date: 2005-11-10 Impact factor: 9.408
Authors: Donald Lloyd-Jones; Robert J Adams; Todd M Brown; Mercedes Carnethon; Shifan Dai; Giovanni De Simone; T Bruce Ferguson; Earl Ford; Karen Furie; Cathleen Gillespie; Alan Go; Kurt Greenlund; Nancy Haase; Susan Hailpern; P Michael Ho; Virginia Howard; Brett Kissela; Steven Kittner; Daniel Lackland; Lynda Lisabeth; Ariane Marelli; Mary M McDermott; James Meigs; Dariush Mozaffarian; Michael Mussolino; Graham Nichol; Véronique L Roger; Wayne Rosamond; Ralph Sacco; Paul Sorlie; Randall Stafford; Thomas Thom; Sylvia Wasserthiel-Smoller; Nathan D Wong; Judith Wylie-Rosett Journal: Circulation Date: 2010-02-23 Impact factor: 29.690
Authors: Alireza Amirzadegan; Gholamreza Davoodi; Mohammad Ali Boroumand; Sirous Darabyan; Maria Raissi Dehkordi; Hamidreza Goodarzynejad Journal: Indian J Med Sci Date: 2007-12
Authors: Raúl Herzog; María José Álvarez-Pasquin; Camino Díaz; José Luis Del Barrio; José Manuel Estrada; Ángel Gil Journal: BMC Public Health Date: 2013-02-19 Impact factor: 3.295